ArticleWorld journal of gastroenterology2009
IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis.African health sciences · 2016Pooled it
- Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility.World journal of gastroenterology · 2014Pooled it
- Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease.Molecular biology reports · 2014Pooled it
- A meta-analysis on the association between three promoter variants of TNF-α and Crohn's disease.Molecular biology reports · 2012Pooled it
- The relationship between IL-10 levels, gene polymorphisms and histiocytic necrotizing lymphadenitis in children.BMC pediatrics · 2026Article
- Evaluation of the association between TNF-α-1031 T/C polymorphism with oral lichen planus disease.BMC oral health · 2024Article
- TNF-α-1031T/C gene polymorphism as a predictor of malnutrition in patients with gastric cancer.Frontiers in nutrition · 2023Article
- Association of polymorphisms in the IL-10 promoter region with Crohn's disease.Journal of clinical laboratory analysis · 2022Article
- Activation pathways that drive CD4Immunological reviews · 2022Review
- Relationship between TNF-α -1031T/C gene polymorphism, plasma level of TNF-α, and risk of cachexia in head and neck cancer patients.Journal of cancer research and clinical oncology · 2018Article
- Effector T Helper Cell Subsets in Inflammatory Bowel Diseases.Frontiers in immunology · 2018Review
- Evaluation of tumor necrosis factor (TNF)-α mRNA expression level and the rs1799964 polymorphism of the TNF-α gene in peripheral mononuclear cells of patients with inflammatory bowel diseases.Biomedical reports · 2017Article
- ACC interleukin-10 gene promoter haplotype as a breast cancer risk factor predictor among Jordanian females.OncoTargets and therapy · 2016Article
- Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Article
- Association of Tumor Necrosis Factor Alpha Gene Polymorphisms with Inflammatory Bowel Disease in Iran.Iranian journal of public health · 2014Article
- Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.Advances in immunology · 2014Review
- Interaction ofImmunology and infectious diseases · 2013Article
- Why interleukin-10 supplementation does not work in Crohn's disease patients.World journal of gastroenterology · 2013Review
- Structure of tumor necrosis factor-alpha haploblocks in European populations.Immunogenetics · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-alpha and the interleukin (IL)-10 in childhood Crohn's disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.
methodsTen variants in GR, TNF-alpha and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin.
resultsFor the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5'flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians (GCC, ACC and ATA) and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of five polymorphisms in the promoter region of the TNF-alpha gene (-1031 T > C, -863 A > C, -857 T > C, -308 A > G and -238 A > G) revealed a significant overrepresentation of homozygous -1031 CC among CD patients (OR = 9.9) and an association with the colonic location. For TNF-alpha, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.
conclusionThis is one of the first studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD.
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