ArticleProtein science : a publication of the Protein Society2009
The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides.
Article in Protein science : a publication of the Protein Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Cephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).Journal of insect science (Online) · 2024Article
- Decoupled evolution of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Destructive effects of UVC radiation on Drosophila melanogaster: Mortality, fertility, mutations, and molecular mechanisms.PloS one · 2024Article
- Decoupled evolution of thebioRxiv : the preprint server for biology · 2023Article
- Identification and Functional Analysis of G Protein-Coupled Receptors in 20-Hydroxyecdysone Signaling From theFrontiers in cell and developmental biology · 2021Article
- Microbiome interactions shape host fitness.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family.Scientific reports · 2016Article
- Article
- Sexual conflict and seminal fluid proteins: a dynamic landscape of sexual interactions.Cold Spring Harbor perspectives in biology · 2014Review
- Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance.Aging cell · 2013Article
- Phylogenetic investigation of Peptide hormone and growth factor receptors in five dipteran genomes.Frontiers in endocrinology · 2013Article
- More than two decades of research on insect neuropeptide GPCRs: an overview.Frontiers in endocrinology · 2012Article
- Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila.Molecular biology and evolution · 2012Article
- Transcriptome analysis of the desert locust central nervous system: production and annotation of a Schistocerca gregaria EST database.PloS one · 2011Article
- Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor.Cellular and molecular life sciences : CMLS · 2010Article
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Abstract
Methuselah (Mth) is a G protein-coupled receptor (GPCR) associated with longevity in Drosophila melanogaster. Previously, Stunted (Sun) was identified as a peptide agonist of Mth. Here, we identify two additional activators of Mth signaling: Drosophila Sex Peptide (SP) and a novel peptide (Serendipitous Peptide Activator of Mth, SPAM). Minimal functional sequences and key residues were identified from Sun and SPAM by studying truncation and alanine-scanning mutations. These peptide agonists share little sequence homology and illustrate the promiscuity of Mth for activation. mth mutants exhibit no defects in behaviors controlled by SP, casting doubt on the biological significance of Mth activation by any of these agonists, and illustrating the difficulty in applying in vitro studies to their relevance in vivo. Future studies of Mth ligands will help further our understanding of the functional interaction of agonists and GPCRs.
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