ArticleMolecular biotechnology2009
Serial expression analysis of liver regeneration-related genes in rat regenerating liver.
Article in Molecular biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Unveiling the effect of chia seeds and matcha tea on growth performance, metabolism, carcass characteristics, and gene expression on New Zealand rabbits.Scientific reports · 2025Article
- Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease?International journal of biological sciences · 2021Article
- Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy.Stem cell research & therapy · 2017Article
- Article
- Proteomic analysis of the regenerating liver following 2/3 partial hepatectomy in rats.Biological research · 2014Article
- Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes.BMC complementary and alternative medicine · 2014Article
- ECR-MAPK regulation in liver early development.BioMed research international · 2014Article
- Analysis of the role of the integrin signaling pathway in hepatocytes during rat liver regeneration.Cellular & molecular biology letters · 2012Article
- Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration.Journal of genetics · 2011Article
- Correlation analysis between gene expression profile of rat liver tissues and high-fat emulsion-induced nonalcoholic fatty liver.Digestive diseases and sciences · 2011Article
- Role of the autonomic nervous system in rat liver regeneration.Cellular and molecular neurobiology · 2011Article
- Analysis of time-course gene expression profiles of sinusoidal endothelial cells during liver regeneration in rats.Molecular and cellular biochemistry · 2011Article
- Analysis of gene expression profiles of liver stellate cells during liver regeneration in rats.Molecules and cells · 2011Article
- Transcriptome analysis of hepatocytes after partial hepatectomy in rats.Development genes and evolution · 2010Article
- Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the gene expression changes in rat hepatic restoration with Rat Genome 230 2.0 chip containing 11,789 known genes and 13,231 unknown genes (taking up 90 percent of rat whole genome) following a 2/3 hepatectomy. The expression profiles and roles of these genes in rat liver regeneration (LR) were assayed using bioinformatics and systems biology method. Among the above genes, 1,004 known genes and 857 unknown genes were found to be associated with rat LR. The numbers of the known genes up-regulated, down-regulated, and up/down-regulated were 622, 443, and 15, respectively; that of the unknown genes were 367, 400, and 14, respectively. Out of the above two groups of genes, the ones up- and down-regulated 20 times or more were 62 and 38, 8, and 14, respectively. Notably, The highest expression level of dehydrogenase/reductase member 7 (DHRS7) was more than 968-fold compared to control, and alpha-1-B glycoprotein (A1BG), the product of gene with the lowest expression abundance, was 58 times lower than control. During rat liver regeneration, 467 up-regulated, 282 down-regulated, 10 up/down-regulated genes, and 1,031 undetected genes in our study interacted with each other and formed a network with a total of 4,014 connectivities. Among them, the genes for the regulation, synthesis, transport, signal transduction, protein modification, and physiological response formed 630, 290, 691, 373, 2010, and 20 connectivities, respectively; and the genes jun, fos, myc, ptgs2, ccna2, ccl2 had relatively higher degree of connectivity. The results indicated that cell apoptosis and inflammatory response were enhanced in the initial phase and the early part of progressive phase in LR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.