ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2009
Hyperventilation during orthostatic challenge in spinal cord-injured humans.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans.European journal of applied physiology · 2013Article
- Hypoventilation during passive leg movement in spinal cord-injured humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether arterial hypotension is related to hyperventilation during standing in individuals with complete spinal cord injury (SCI).
methodsSixteen individuals with SCI (thoracic 1 to thoracic level 12, ASIA grade: A) and 18 able-bodied individuals participated in this study. Individuals with SCI were divided into a group with injury level at or above thoracic (T) 7 [higher SCI (HSCI), n = 9] and a group with injury level at or below T10 (lower SCI, n = 7). Subjects carried out 6-min quiet sitting and then 6-min quiet standing using a standing frame.
resultsSignificant decrease in mean arterial blood pressure (MAP) and significant increase in minute ventilation (V(E)) by postural change from sitting to standing were observed only in HSCI. In HSCI, MAP decreased from 81 +/- 11 to 75 +/- 16 mmHg (P < 0.05), while V(E) increased from 8.4 +/- 1.1 to 9.9 +/- 1.0 l min(-1) (P < 0.01). There was a significant negative correlation between changes in MAP and V(E) in subjects in the HSCI group (r = -0.72, P < 0.05).
interpretationWe concluded that the magnitude of hyperventilation during standing is associated with individual difference in the magnitude of hypotension in individuals with SCI. The mechanism(s) for this relationship remains unresolved, but afferent signals from baroreceptors to the brainstem respiratory center and/or action of pressor substances on the central nervous system might have caused hyperventilation.
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