Trial reportPsychopharmacology2009
The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Individual differences in dopamine-related traits influence mood effects of dopamine D2-antagonist and antidepressant treatment expectations.The international journal of neuropsychopharmacology · 2025Trial
- Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo.Molecular psychiatry · 2025Trial
- Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans.PLoS biology · 2024Trial
- Pramipexole modulates fronto-subthalamic pathway in sequential working memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects.The international journal of neuropsychopharmacology · 2015Trial
- Dopamine modulates the neural representation of subjective value of food in hungry subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Role of dopamine D2 receptors in human reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.PloS one · 2014Trial
- Human cognitive flexibility depends on dopamine D2 receptor signaling.Psychopharmacology · 2011Trial
- Never too late to start musical instrument training: Effects on working memory and subcortical preservation in healthy older adults across 4 years.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.Nature communications · 2022Article
- Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.Frontiers in psychology · 2021Article
- Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.Schizophrenia research · 2020Article
- Article
- Effects of dopamine D2/D3 receptor antagonism on human planning and spatial working memory.Translational psychiatry · 2017Article
- The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity.Advances in neurotoxicology · 2017Article
- COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.The pharmacogenomics journal · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleDopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear.
objectiveThe present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for the manipulation of information in working memory.
methodsTwenty healthy human subjects were scanned twice, once after placebo and once after sulpiride 400 mg, a selective DA D2 receptor antagonist, while performing a verbal working memory task requiring different levels of manipulation.
resultsWhilst there was no overall effect of sulpiride on task-dependent activation, individual variation in sulpiride plasma levels predicted the effect of working memory manipulation on activation in the putamen, suggesting a dose-dependent effect of DA antagonism on a striatally based manipulation process. These effects occurred in the context of a drug-induced improvement in performance on trials requiring the manipulation of information in working memory but not on simple retrieval trials. No significant drug effects were observed in the prefrontal cortex.
conclusionsThese results support models of dopamine function that posit a 'gating' function for dopamine D2 receptors in the striatum, which enables the flexible updating and manipulation of information in working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.