ArticlePloS one2009
Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure.PloS one · 2025Article
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Divergent Cardiac Effects of Angiotensin II and Isoproterenol Following Juvenile Exposure to Doxorubicin.Frontiers in cardiovascular medicine · 2022Article
- Article
- Effects of genetic background, sex, and age on murine atrial electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- B-arrestin-2 Signaling Is Important to Preserve Cardiac Function During Aging.Frontiers in physiology · 2021Article
- Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice.Journal of visualized experiments : JoVE · 2019Article
- Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans.G3 (Bethesda, Md.) · 2018Article
- Genetic background dominates the susceptibility to ventricular arrhythmias in a murine model of β-adrenergic stimulation.Scientific reports · 2018Article
- Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.Circulation. Heart failure · 2017Article
- Ganglionic GFAPJCI insight · 2017Article
- Strain survey and genetic analysis of vasoreactivity in mouse aorta.Physiological genomics · 2016Article
- Chronic β1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium.European journal of pharmacology · 2016Article
- RNAseq analysis of heart tissue from mice treated with atenolol and isoproterenol reveals a reciprocal transcriptional response.BMC genomics · 2016Article
- Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation.Molecular medicine (Cambridge, Mass.) · 2016Article
- Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.Journal of molecular and cellular cardiology · 2015Article
- Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice.Circulation. Cardiovascular genetics · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in response to chronic administration of a single dose of the beta-adrenergic receptor blocker atenolol or under a low and a high dose of the beta-agonist isoproterenol and compared to baseline condition. The robustness of our data is supported by high trait heritabilities (typically H(2)>0.7) and significant correlations of trait values measured in baseline condition with independent multistrain datasets of the Mouse Phenome Database. We then focused on the drug-, dose-, and strain-specific responses to beta-stimulation and beta-blockade of a selection of traits including heart rate, systolic blood pressure, cardiac weight indices, ECG parameters and body weight. Because of the wealth of data accumulated, we applied integrative analyses such as comprehensive bi-clustering to investigate the structure of the response across the different phenotypes, strains and experimental conditions. Information extracted from these analyses is discussed in terms of novelty and biological implications. For example, we observe that traits related to ventricular weight in most strains respond only to the high dose of isoproterenol, while heart rate and atrial weight are already affected by the low dose. Finally, we observe little concordance between strain similarity based on the phenotypes and genotypic relatedness computed from genomic SNP profiles. This indicates that cardiovascular phenotypes are unlikely to segregate according to global phylogeny, but rather be governed by smaller, local differences in the genetic architecture of the various strains.
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