ArticleJournal of biomedicine & biotechnology2009
Characterization of multidrug resistant ESBL-producing Escherichia coli isolates from hospitals in Malaysia.
Article in Journal of biomedicine & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Silent Reservoirs: Antibiotic-ResistantPathogens (Basel, Switzerland) · 2026Article
- Alarming colistin and carbapenem resistance in Klebsiella pneumoniae: molecular insights from Tehran hospitals, Iran.BMC research notes · 2025Article
- Extended Spectrum Beta-Lactamase Producing Escherichia coli in Pet Cats and Dogs in Central Peninsular Malaysia.Veterinary medicine and science · 2025Article
- Import of global high-risk clones is the primary driver of carbapenemase-producingJournal of medical microbiology · 2025Article
- Dairy Cattle and the Iconic Autochthonous Cattle in Northern Portugal Are Reservoirs of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Extended spectrum beta-lactamase and aminoglycoside modifying enzyme genes in multi drug resistant Gram-negative bacteria: A snapshot from a tertiary care centre.Medical journal, Armed Forces India · 2024Article
- Prevalence and molecular characterization of ESBL-producing Escherichia coli isolated from broiler chicken and their respective farms environment in Malaysia.BMC microbiology · 2024Article
- Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negativeFrontiers in cellular and infection microbiology · 2024Article
- Characterization of Beta-Lactam Resistome ofAntibiotics (Basel, Switzerland) · 2023Article
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- Prevalence and Diversity of Antibiotic ResistantFrontiers in public health · 2022Article
- A Cross-Sectional Study to Evaluate Antimicrobial Susceptibility of Uropathogens from South Punjab, Pakistan.Infection and drug resistance · 2022Article
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- Multidrug-Resistant, Including Extended-Spectrum Beta Lactamase-Producing and Quinolone-Resistant,Antibiotics (Basel, Switzerland) · 2021Article
- Occurrence of Multidrug ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Occurrence and Characteristics of Extended-Spectrum β-Lactamase-ProducingPathogens (Basel, Switzerland) · 2020Article
- High occurrence of CMY-2-type beta-lactamase-producing Escherichia coli among broiler flocks in Turkey.Tropical animal health and production · 2020Article
- Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand.The Journal of veterinary medical science · 2018Article
- Occurrence of virulent and antibiotic-resistant Shiga toxin-producingVeterinary world · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of Escherichia coli that produce extended spectrum beta-lactamases (ESBLs) and are multidrug resistant (MDR) poses antibiotic management problems. Forty-seven E. coli isolates from various public hospitals in Malaysia were studied. All isolates were sensitive to imipenem whereas 36 were MDR (resistant to 2 or more classes of antibiotics). PCR detection using gene-specific primers showed that 87.5% of the ESBL-producing E. coli harbored the blaTEM gene. Other ESBL-encoding genes detected were blaOXA, blaSHV, and blaCTX-M. Integron-encoded integrases were detected in 55.3% of isolates, with class 1 integron-encoded intI1 integrase being the majority. Amplification and sequence analysis of the 5'CS region of the integrons showed known antibiotic resistance-encoding gene cassettes of various sizes that were inserted within the respective integrons. Conjugation and transformation experiments indicated that some of the antibiotic resistance genes were likely plasmid-encoded and transmissible. All 47 isolates were subtyped by PFGE and PCR-based fingerprinting using random amplified polymorphic DNA (RAPD), repetitive extragenic palindromes (REPs), and enterobacterial repetitive intergenic consensus (ERIC). These isolates were very diverse and heterogeneous. PFGE, ERIC, and REP-PCR methods were more discriminative than RAPD in subtyping the E. coli isolates.
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Registered trials
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