Trial reportEnvironmental health perspectives2009
Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone.
Trial report in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Short-term exposure to particulate matter on heart rate variability in humans: a systematic review of crossover and controlled studies.Environmental science and pollution research international · 2021Pooled it
- Effects of urban fine particulate matter and ozone on HDL functionality.Particle and fibre toxicology · 2016Trial
- Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects.American journal of physiology. Heart and circulatory physiology · 2015Trial
- Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.Inhalation toxicology · 2015Trial
- Diesel exhaust modulates ozone-induced lung function decrements in healthy human volunteers.Particle and fibre toxicology · 2014Trial
- Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists.Environmental health perspectives · 2011Trial
- Trial
- Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone.Cardiovascular toxicology · 2024Article
- Concentration-Response Functions Relating Concentration and Duration of Ambient Traffic-Related Air Pollution Exposure to Systolic Blood Pressure.Environmental health perspectives · 2024Article
- The synergistic effect of high temperature and ozone on the number of deaths from circulatory system diseases in Shijiazhuang, China.Frontiers in public health · 2023Article
- Spatiotemporal assessment of health burden and economic losses attributable to short-term exposure to ground-level ozone during 2015-2018 in China.BMC public health · 2021Article
- Article
- Associations between acute exposure to ambient air pollution and length of stay for inpatients with ischemic heart disease: a multi-city analysis in central China.Environmental science and pollution research international · 2020Article
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- Environmental determinants of cardiovascular disease: lessons learned from air pollution.Nature reviews. Cardiology · 2020Review
- Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. Effects of Personal and Ambient Concentrations of Ozone and Other Pollutants on Cardiovascular and Pulmonary Function.Research report (Health Effects Institute) · 2020Article
- Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice.Journal of toxicology and environmental health. Part A · 2019Article
- Ozone Pollution: A Major Health Hazard Worldwide.Frontiers in immunology · 2019Review
- Adaptive predictive principal components for modeling multivariate air pollution.Environmetrics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHuman controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown.
objectiveIn this study we assessed the impact of O(3) and particulate matter exposure on HRV in humans.
methodsIn a crossover design, 50 subjects (19-48 years of age) were randomized to 2-hr controlled exposures to filtered air (FA), concentrated ambient particles (CAPs), O(3), or combined CAPs and ozone (CAPs + O(3)). The primary end point was change in HRV between the start and end of exposure. Secondary analyses included blood pressure (BP) responses, and effect modification by asthmatic status.
resultsAchieved mean CAPs and O(3) exposure concentrations were 121.6 +/- 48.0 microg/m(3) and 113.9 +/- 6.6 ppb, respectively. In a categorical analysis, exposure had no consistent effect on HRV indices. However, the dose-response relationship between CAPs mass concentration and HRV indices seemed to vary depending on the presence of O(3). This heterogeneity was statistically significant for the low-frequency component of HRV (p = 0.02) and approached significance for the high-frequency component and time-domain measures of HRV. Exposure to CAPs + O(3) increased diastolic BP by 2.0 mmHg (SE, 1.2; p = 0.02). No other statistically significant changes in BP were observed. Asthmatic status did not modify these effects.
conclusionThe potentiation by O(3) of CAPs effects on diastolic BP and possibly HRV is of small magnitude in young adults. Further studies are needed to assess potential effects in more vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.