ReviewEnvironmental health perspectives2009
A reconsideration of acute Beryllium disease.
Review in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration.GeoHealth · 2025Review
- Impact of Epidemic Intelligence Service Training in Occupational Respiratory Epidemiology.ATS scholar · 2023Article
- Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats.Pharmaceutical biology · 2022Article
- TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Macrophages and fibroblasts during inflammation and tissue repair in models of organ regeneration.Regeneration (Oxford, England) · 2017Review
- Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease.Journal of occupational and environmental medicine · 2016Article
- Effects of beryllium on human serum immunoglobulin and lymphocyte subpopulation.Toxicological research · 2013Article
- Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs.PloS one · 2013Article
- The role of lymphocyte proliferation tests in assessing occupational sensitization and disease.Current opinion in allergy and clinical immunology · 2012Review
- Objective assessment of an ionic footbath (IonCleanse): testing its ability to remove potentially toxic elements from the body.Journal of environmental and public health · 2012Article
- Pulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesis.Journal of toxicologic pathology · 2011Article
- Chronic beryllium disease: an updated model interaction between innate and acquired immunity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2011Review
- Beryllium metal II. a review of the available toxicity data.The Annals of occupational hygiene · 2011Review
- Advances in identifying beryllium sensitization and disease.International journal of environmental research and public health · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
contextAlthough chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the patho physiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers. CASE PRESENTATION: Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 microg/m(3), and most were < 10 microg/m(3), lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD. DISCUSSION: Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved. RELEVANCE TO PRACTICE: ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.