ArticlePloS one2009
Are small GTPases signal hubs in sugar-mediated induction of fructan biosynthesis?
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- High-Throughput Extraction and Enzymatic Determination of Sugars and Fructans in Fructan-Accumulating Plants.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Molecular Mechanism Underlying Derepressed Male Production in Hexaploid Persimmon.Frontiers in plant science · 2020Article
- Tyrosine Kinase-Dependent Defense Responses Against Herbivory in Arabidopsis.Frontiers in plant science · 2019Article
- Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots.Scientific reports · 2016Article
- Presence of Inulin-Type Fructo-Oligosaccharides and Shift from Raffinose Family Oligosaccharide to Fructan Metabolism in Leaves of Boxtree (Buxus sempervirens).Frontiers in plant science · 2016Article
- Members of the Plant CRK Superfamily Are Capable of Trans- and Autophosphorylation of Tyrosine Residues.The Journal of biological chemistry · 2015Article
- Changes in the abundance of sugars and sugar-like compounds in tall fescue (Festuca arundinacea) due to growth in naphthalene-treated sand.Environmental science and pollution research international · 2015Article
- TaMYB13-1, a R2R3 MYB transcription factor, regulates the fructan synthetic pathway and contributes to enhanced fructan accumulation in bread wheat.Journal of experimental botany · 2013Article
- Sucrose signaling in plants: a world yet to be explored.Plant signaling & behavior · 2013Review
- Towards understanding vacuolar antioxidant mechanisms: a role for fructans?Journal of experimental botany · 2013Article
- Article
- Dissecting the molecular basis of the contribution of source strength to high fructan accumulation in wheat.Plant molecular biology · 2013Article
- Kinome profiling.Scientifica · 2012Review
- Deciphering enzyme function using peptide arrays.Molecular biotechnology · 2011Review
- Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment.Journal of proteome research · 2011Article
- Article
- Kinome profiling of sugar signaling in plants using multiple platforms.Plant signaling & behavior · 2009Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
External sugar initiates biosynthesis of the reserve carbohydrate fructan, but the molecular processes mediating this response remain obscure. Previously it was shown that a phosphatase and a general kinase inhibitor hamper fructan accumulation. We use various phosphorylation inhibitors both in barley and in Arabidopsis and show that the expression of fructan biosynthetic genes is dependent on PP2A and different kinases such as Tyr-kinases and PI3-kinases. To further characterize the phosphorylation events involved, comprehensive analysis of kinase activities in the cell was performed using a PepChip, an array of >1000 kinase consensus substrate peptide substrates spotted on a chip. Comparison of kinase activities in sugar-stimulated and mock(sorbitol)-treated Arabidopsis demonstrates the altered phosphorylation of many consensus substrates and documents the differences in plant kinase activity upon sucrose feeding. The different phosphorylation profiles obtained are consistent with sugar-mediated alterations in Tyr phosphorylation, cell cycling, and phosphoinositide signaling, and indicate cytoskeletal rearrangements. The results lead us to infer a central role for small GTPases in sugar signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.