ArticlePloS one2009
In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 152 citations in OpenAlex.
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- Toxicological and Physiological Responses to Combined Ultrasound and Lipid-Coated ZnO Nanoparticle Exposure inACS applied materials & interfaces · 2026Article
- Labeling of Amine-Modified Material Surfaces with PFB-Fluorescein.Nanotechnology, science and applications · 2026Article
- Natures' tiny heaters: a bioinspired approach to magnetic hyperthermia and C. elegans nanotoxicity.World journal of microbiology & biotechnology · 2025Article
- Reproductive Toxicity of Nanoparticles: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications.Journal of nanobiotechnology · 2024Review
- Nanobiotechnology in crop stress management: an overview of novel applications.Discover nano · 2023Review
- Dietary Transfer of Zinc Oxide Nanoparticles Induces Locomotive Defects Associated with GABAergic Motor Neuron Damage inNanomaterials (Basel, Switzerland) · 2023Article
- Neurotoxicology of metals and metallic nanoparticles inAdvances in neurotoxicology · 2023Article
- Exposome, Molecular Pathways and One Health: The InvertebrateInternational journal of molecular sciences · 2022Review
- Effects of Amorphous Silica Nanopowders on the Avoidance Behavior of Five Soil Species-A Screening Study.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Comparative toxicity of a food additive TiOEnvironmental science and pollution research international · 2019Article
- Matricidal hatching can induce multi-generational effects in nematode Caenorhabditis elegans after dietary exposure to nanoparticles.Environmental science and pollution research international · 2018Article
- Toxicity interactions between manganese (Mn) and lead (Pb) or cadmium (Cd) in a model organism the nematode C. elegans.Environmental science and pollution research international · 2018Article
- Sublethal Effects of Ionic and Nanogold on the NematodeJournal of toxicology · 2018Article
- Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organismMaterials horizons · 2017Article
- TheBiochemistry and biophysics reports · 2017Article
- Shorter lifetime of a soil invertebrate species when exposed to copper oxide nanoparticles in a full lifespan exposure test.Scientific reports · 2017Article
- Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride inInternational journal of nanomedicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While expectations and applications of nanotechnologies grow exponentially, little is known about interactions of engineered nanoparticles with multicellular organisms. Here we propose the transparent roundworm Caenorhabditis elegans as a simple but anatomically and biologically well defined animal model that allows for whole organism analyses of nanoparticle-bio-interactions. Microscopic techniques showed that fluorescently labelled nanoparticles are efficiently taken up by the worms during feeding, and translocate to primary organs such as epithelial cells of the intestine, as well as secondary organs belonging to the reproductive tract. The life span of nanoparticle-fed Caenorhabditis elegans remained unchanged, whereas a reduction of progeny production was observed in silica-nanoparticle exposed worms versus untreated controls. This reduction was accompanied by a significant increase of the 'bag of worms' phenotype that is characterized by failed egg-laying and usually occurs in aged wild type worms. Experimental exclusion of developmental defects suggests that silica-nanoparticles induce an age-related degeneration of reproductive organs, and thus set a research platform for both, detailed elucidation of molecular mechanisms and high throughput screening of different nanomaterials by analyses of progeny production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.