ReviewScience signaling2009
Actin and microtubule-based cytoskeletal cues direct polarized targeting of proteins in neurons.
Review in Science signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation.Scientific reports · 2023Article
- EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor.Cells · 2021Review
- Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids.Epigenetics & chromatin · 2021Article
- Spatial control of membrane traffic in neuronal dendrites.Molecular and cellular neurosciences · 2020Review
- Integrins promote axonal regeneration after injury of the nervous system.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Proteomics Reveals the Molecular Underpinnings of Stronger Learning and Memory in Eastern Compared to Western Bees.Molecular & cellular proteomics : MCP · 2018Article
- Cue-Polarized Transport of β-actin mRNA Depends on 3'UTR and Microtubules in Live Growth Cones.Frontiers in cellular neuroscience · 2018Article
- EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment.Journal of cell science · 2017Article
- The cellular mechanisms that maintain neuronal polarity.Nature reviews. Neuroscience · 2016Review
- Techniques for studying protein trafficking and molecular motors in neurons.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities.Brain and behavior · 2015Article
- Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Review
- Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Structure meets function: actin filaments and myosin motors in the axon.Journal of neurochemistry · 2014Review
- Selective microtubule-based transport of dendritic membrane proteins arises in concert with axon specification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.The Journal of biological chemistry · 2013Article
- Review
- Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots.Scientific reports · 2013Article
- Networks of polarized actin filaments in the axon initial segment provide a mechanism for sorting axonal and dendritic proteins.Cell reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Neuronal proteins are transported to either the axon or dendrites through the action of kinesin motors; however, understanding of how cytoskeletal elements steer these cargo-motor complexes to one compartment or the other has remained elusive. Three recent developments-the discovery of an actin-based filter within the axon initial segment, the identification of the pivotal role played by myosin motors in dendritic targeting, and the determination of the properties of a kinesin motor that cause it to prefer axonal to dendritic microtubules-have now provided a structural framework for understanding polarized targeting in neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.