ArticleThe Plant cell2009
Proteolysis of a negative regulator of innate immunity is dependent on resistance genes in tomato and Nicotiana benthamiana and induced by multiple bacterial effectors.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
- Subcellular targets and recognition mechanism ofiScience · 2025Article
- A genome-wide association study identifies candidate genes for target leaf spot disease resistance in adult cucumber (Frontiers in plant science · 2025Article
- Protein Disorder in Plant Stress Adaptation: From Late Embryogenesis Abundant to Other Intrinsically Disordered Proteins.International journal of molecular sciences · 2024Review
- Suppression of NLR-mediated plant immune detection by bacterial pathogens.Journal of experimental botany · 2023Review
- CaREM1.4 interacts with CaRIN4 to regulateHorticulture research · 2023Article
- Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance inFrontiers in plant science · 2023Article
- The Upregulated Expression of the CitrusInternational journal of molecular sciences · 2022Article
- Article
- Comparative and evolutionary analysis of Arabidopsis RIN4-like/NOI proteins induced by herbivory.PloS one · 2022Article
- Plant Protein Disorder: Spatial Regulation, Broad Specificity, Switch of Signaling and Physiological Status.Frontiers in plant science · 2022Article
- RIN4 homologs from important crop species differentially regulate the Arabidopsis NB-LRR immune receptor, RPS2.Plant cell reports · 2021Article
- Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation.PLoS pathogens · 2021Article
- Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity.Microbiological research · 2021Review
- Understanding and Exploiting Post-Translational Modifications for Plant Disease Resistance.Biomolecules · 2021Review
- Review
- Heterologous Expression of PKPI and Pin1 Proteinase Inhibitors Enhances Plant Fitness and Broad-Spectrum Resistance to Biotic Threats.Frontiers in plant science · 2020Article
- Role of RIN4 in Regulating PAMP-Triggered Immunity and Effector-Triggered Immunity: Current Status and Future Perspectives.Molecules and cells · 2019Review
- TheFrontiers in plant science · 2019Article
- Regulated Disorder: Posttranslational Modifications Control the RIN4 Plant Immune Signaling Hub.Molecular plant-microbe interactions : MPMI · 2019Review
- Genome-wide identification, characterization, and evolutionary analysis of NBS-encoding resistance genes in barley.3 Biotech · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RPM1-interacting protein 4 (RIN4), a negative regulator of the basal defense response in plants, is targeted by multiple bacterial virulence effectors. We show that RIN4 degradation is induced by the effector AvrPto from Pseudomonas syringae and that this degradation in Solanaceous plants is dependent on the resistance protein, Pto, a protein kinase, and Prf, a nucleotide binding site-leucine-rich repeat protein. Our data demonstrate overlap between two of the best-characterized pathways for recognition of pathogen virulence effectors in plants. RIN4 interacts with multiple plant signaling components and bacterial effectors in yeast and in planta. AvrPto induces an endogenous proteolytic activity in both tomato (Solanum lycopersicum) and Nicotiana benthamiana that degrades RIN4 and requires the consensus site cleaved by the protease effector AvrRpt2. The interaction between AvrPto and Pto, but not the kinase activity of Pto, is required for proteolysis of RIN4. Analysis of many of the effectors comprising the secretome of P. syringae pv tomato DC3000 led to the identification of two additional sequence-unrelated effectors that can also induce degradation of RIN4. Therefore, multiple bacterial effectors besides AvrRpt2 elicit proteolysis of RIN4 in planta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.