ArticleThe Journal of biological chemistry2009
Cyanochromes are blue/green light photoreversible photoreceptors defined by a stable double cysteine linkage to a phycoviolobilin-type chromophore.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Quantum entanglement and coherence in plant signaling networks: a theoretical framework.Theory in biosciences = Theorie in den Biowissenschaften · 2026Review
- Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress.International journal of molecular sciences · 2023Review
- Review
- Vibrational Spectroscopy of Phytochromes.Biomolecules · 2023Review
- The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ.Physical chemistry chemical physics : PCCP · 2023Article
- Differential Phototactic Behavior of Closely Related Cyanobacterial Isolates from Yellowstone Hot Spring Biofilms.Applied and environmental microbiology · 2022Article
- Pump-Probe Circular Dichroism Spectroscopy of Cyanobacteriochrome TePixJ Yields: Insights into Its Photoconversion.The journal of physical chemistry. B · 2021Article
- A far-red cyanobacteriochrome lineage specific for verdins.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Photocycle of Cyanobacteriochrome TePixJ.Biochemistry · 2020Article
- Photoreversible interconversion of a phytochrome photosensory module in the crystalline state.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Protochromic absorption changes in the two-cysteine photocycle of a blue/orange cyanobacteriochrome.The Journal of biological chemistry · 2019Article
- Chromophore binding to two cysteines increases quantum yield of near-infrared fluorescent proteins.Scientific reports · 2019Article
- Diverse light responses of cyanobacteria mediated by phytochrome superfamily photoreceptors.Nature reviews. Microbiology · 2019Review
- Cyanobacteria Respond to Low Levels of Ethylene.Frontiers in plant science · 2019Article
- Chromophorylation of cyanobacteriochrome Slr1393 fromThe Journal of biological chemistry · 2018Article
- Ethylene causes transcriptomic changes inPlant direct · 2018Article
- Moving toward Light in Response to a Gas: A Novel Cyanobacterial Ethylene Receptor.Plant physiology · 2016Article
- Ethylene Regulates the Physiology of the Cyanobacterium Synechocystis sp. PCC 6803 via an Ethylene Receptor.Plant physiology · 2016Article
- Spectral properties of bacteriophytochrome AM1_5894 in the chlorophyll d-containing cyanobacterium Acaryochloris marina.Scientific reports · 2016Article
- Phytochromes: an atomic perspective on photoactivation and signaling.The Plant cell · 2014Review
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Phytochromes are a collection of bilin-containing photoreceptors that regulate a diverse array of processes in microorganisms and plants through photoconversion between two stable states, a red light-absorbing Pr form, and a far red light-absorbing Pfr form. Recently, a novel set of phytochrome-like chromoproteins was discovered in cyanobacteria, designated here as cyanochromes, that instead photoconvert between stable blue and green light-absorbing forms Pb and Pg, respectively. Here, we show that the distinctive absorption properties of cyanochromes are facilitated through the binding of phycocyanobilin via two stable cysteine-based thioether linkages within the cGMP phosphodiesterase/adenyl cyclase/FhlA domain. Absorption, resonance Raman and infrared spectroscopy, and molecular modeling of the Te-PixJ GAF (cGMP phosphodiesterase/adenyl cyclase/FhlA) domain assembled with phycocyanobilin are consistent with attachments to the C3(1) carbon of the ethylidene side chain and the C4 or C5 carbons in the A-B methine bridge to generate a double thioether-linked phycoviolobilin-type chromophore. These spectroscopic methods combined with NMR data show that the bilin is fully protonated in the Pb and Pg states and that numerous conformation changes occur during Pb --> Pg photoconversion. Also identified were a number of photochromically inactive mutants with strong yellow or red fluorescence that may be useful for fluorescence-based cell biological assays. Phylogenetic analyses detected cyanochromes capable of different signaling outputs in a wide range of cyanobacterial species. One unusual case is the Synechocystis cyanochrome Etr1 that also binds ethylene, suggesting that it works as a hybrid receptor to simultaneously integrate light and hormone signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.