ArticlePhysiological genomics2009
Effects of atherogenic diet on hepatic gene expression across mouse strains.
Article in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis.Genome research · 2024Pooled it
- Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan.Ageing research reviews · 2012Pooled it
- Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma.International journal of molecular sciences · 2023Review
- Macronutrient modulation of mRNA and microRNA function in animals: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Review
- As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater.International journal of molecular sciences · 2020Article
- Review
- Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams.Scientific reports · 2019Article
- One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.Environment international · 2019Article
- A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice.BMC genomics · 2018Article
- Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice.International journal of molecular sciences · 2018Article
- Article
- Single subject transcriptome analysis to identify functionally signed gene set or pathway activity.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2018Article
- Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.Scientific reports · 2016Article
- Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.PLoS genetics · 2016Article
- Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle.BMC genomics · 2015Article
- Article
- Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice.BMC genomics · 2014Article
- Effects of long-term feeding of the polyphenols resveratrol and kaempferol in obese mice.PloS one · 2014Article
- In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD).International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Diets high in fat and cholesterol are associated with increased obesity and metabolic disease in mice and humans. To study the molecular basis of the metabolic response to dietary fat, 10 inbred strains of mice were fed atherogenic high-fat and control low-fat diets. Liver gene expression and whole animal phenotypes were measured and analyzed in both sexes. The effects of diet, strain, and sex on gene expression were determined irrespective of complex processes, such as feedback mechanisms, that could have mediated the genomic responses. Global gene expression analyses demonstrated that animals of the same strain and sex have similar transcriptional profiles on a low-fat diet, but strains may show considerable variability in response to high-fat diet. Functional profiling indicated that high-fat feeding induced genes in the immune response, indicating liver damage, and repressed cholesterol biosynthesis. The physiological significance of the transcriptional changes was confirmed by a correlation analysis of transcript levels with whole animal phenotypes. The results found here were used to confirm a previously identified quantitative trait locus on chromosome 17 identified in males fed a high-fat diet in two crosses, PERA x DBA/2 and PERA x I/Ln. The gene expression data and phenotype data have been made publicly available as an online tool for exploring the effects of atherogenic diet in inbred mouse strains (http://cgd-array.jax.org/DietStrainSurvey).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.