Evidence map›Paper›PMID 19671628›Full record

ArticleJournal of molecular cell biology2009

Transgenic primate research paves the path to a better animal model: are we a step closer to curing inherited human genetic disorders?

Anthony W S Chan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of molecular cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Pluripotent stem cells models for Huntington's disease: prospects and challenges.Journal of genetics and genomics = Yi chuan xue bao · 2012
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Anthony W S ChanYerkes National Primate Research Center, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30329, USA. awchan@emory.edu
Emory University · US

Funding

Transgenic Huntington's disease monkey resourceR24OD010930 · OD · EMORY UNIVERSITY · PI CHAN, ANTHONY WING SANG · 2012 to 2018
$6.1M
NIH HHS R24 OD010930
6 · The paper itself

Abstract

While the advancement of transgenic primate models has led to a new era in modeling human conditions and has a clear impact on elucidating the mechanism of human genetic diseases, some thoughts should be considered if non-human primates are the appropriate model.

Indexed as

Disease Models, AnimalGenetic ResearchAnimalsAnimals, Genetically ModifiedGenetic Diseases, InbornGenome, HumanHumansPrimates

Identifiers

PMID19671628
PMCPMC6283119
OpenAlexW2120995324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.