ArticleAlcohol (Fayetteville, N.Y.)2009
Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.
Article in Alcohol (Fayetteville, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle.Function (Oxford, England) · 2024Article
- IpsilesionalBrain communications · 2020Article
- Effects of sex on ethanol conditioned place preference, activity and variability in C57BL/6J and DBA/2J mice.Pharmacology, biochemistry, and behavior · 2018Article
- Conditioned effects of ethanol on the immune system.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats.Behavioural brain research · 2014Article
- Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats.Behavioural brain research · 2014Article
- Age-dependent effects of stress on ethanol-induced motor activity in rats.Psychopharmacology · 2013Article
- Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion.Developmental psychobiology · 2013Article
- Prenatal ethanol exposure increases ethanol intake and reduces c-Fos expression in infralimbic cortex of adolescent rats.Pharmacology, biochemistry, and behavior · 2013Article
- μ-Opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation.Pharmacology, biochemistry, and behavior · 2013Article
- Role of mu, delta and kappa opioid receptors in ethanol-reinforced operant responding in infant rats.Behavioural brain research · 2012Article
- Chronic tolerance to the locomotor stimulating effect of ethanol in preweanling rats as a function of social stress.Alcohol (Fayetteville, N.Y.) · 2012Article
- Ontogenetic differences in ethanol's motivational properties during infancy.Alcohol (Fayetteville, N.Y.) · 2012Article
- Early role of the κ opioid receptor in ethanol-induced reinforcement.Physiology & behavior · 2012Article
- The role of social isolation in ethanol effects on the preweanling rat.Behavioural brain research · 2012Article
- Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity.Pharmacology, biochemistry, and behavior · 2012Article
- Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm.Psychopharmacology · 2012Article
- Implicit versus explicit associative learning and experimentally induced placebo hypoalgesia.Journal of pain research · 2011Article
- An acetaldehyde-sequestering agent inhibits appetitive reinforcement and behavioral stimulation induced by ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- Naloxone blocks ethanol-mediated appetitive conditioning and locomotor activation in adolescent rats.Behavioural brain research · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
It has been difficult to find conditioned preference for tactile cues paired with ethanol intoxication in rats. Toward understanding the ontogeny of ethanol reinforcement, we aimed at establishing a simple and reliable procedure for (1) assessing primary appetitive conditioning to ethanol in infant rats and (2) discerning the role the opioid system plays in ethanol-mediated conditioning at this age. Experiment 1 determined the parameters (i.e., dose, interval of conditioning) for assessing ethanol-mediated conditioning. Pups were then trained with differential Pavlovian conditioning (Experiments 2 and 3) in which ethanol intoxication (1.0-2.0 g/kg, intragastrically or intraperitoneally delivered) was paired with a tactile stimulus (sandpaper) while an alternative texture signaled the absence of ethanol's effects. Unpaired control conditions were also used. Tactile preferences were assessed after two conditioning sessions. Paired rats spent significantly more time on sandpaper than unpaired controls, an effect that was greater after intragastric administration of 1.0 than 2.0 g/kg ethanol. This effect was replicated in Experiments 4a and 4c and found to be inhibited by pretreatment with general (naloxone [NAL]) or specific (d-Pen-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH2 [CTOP] and naltrindole) opioid antagonists. Blood ethanol levels at conditioning were not altered by NAL (Experiment 4b). The study outlines a procedure that reveals appetitive conditioning to ethanol by infant rats. The results are discussed in terms of a potential ethanol-induced activation of the endogenous opioid system during the onset of the intoxication process.
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