ArticleBMC cancer2009
Identification of target genes of transcription factor activator protein 2 gamma in breast cancer cells.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views.Journal of translational medicine · 2023Review
- Review
- Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.Genes & genomics · 2020Article
- Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance.EBioMedicine · 2020Article
- AMolecular cancer research : MCR · 2020Article
- Construction and Analysis of Competing Endogenous RNA Networks for Breast Cancer Based on TCGA Dataset.BioMed research international · 2020Article
- AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation.Journal of experimental neuroscience · 2018Article
- TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation.Oncogene · 2017Article
- TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial-mesenchymal transition.Experimental & molecular medicine · 2016Article
- Cancer survival analysis using semi-supervised learning method based on Cox and AFT models with L1/2 regularization.BMC medical genomics · 2016Article
- The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis.Oncogene · 2015Article
- TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.Oncogene · 2015Article
- Article
- Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies.Oncogene · 2014Article
- Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.Acta pharmacologica Sinica · 2013Article
- Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer.Oncogene · 2013Article
- Research resource: preovulatory LH surge effects on follicular theca and granulosa transcriptomes.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.PloS one · 2011Article
- Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells.Genes, chromosomes & cancer · 2010Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActivator protein 2 gamma (AP-2gamma) is a member of the transcription factor activator protein-2 (AP-2) family, which is developmentally regulated and plays a role in human neoplasia. AP-2gamma has been found to be overexpressed in most breast cancers, and have a dual role to inhibit tumor initiation and promote tumor progression afterwards during mammary tumorigensis.
methodsTo identify the gene targets that mediate its effects, we performed chromatin immunoprecipitation (ChIP) to isolate AP-2gamma binding sites on genomic DNA from human breast cancer cell line MDA-MB-453.
results20 novel DNA fragments proximal to potential AP-2gamma targets were obtained. They are categorized into functional groups of carcinogenesis, metabolism and others. A combination of sequence analysis, reporter gene assays, quantitative real-time PCR, electrophoretic gel mobility shift assays and immunoblot analysis further confirmed the four AP-2gamma target genes in carcinogenesis group: ErbB2, CDH2, HPSE and IGSF11. Our results were consistent with the previous reports that ErbB2 was the target gene of AP-2gamma. Decreased expression and overexpression of AP-2gamma in human breast cancer cells significantly altered the expression of these four genes, indicating that AP-2gamma directly regulates them.
conclusionThis suggested that AP-2gamma can coordinate the expression of a network of genes, involving in carcinogenesis, especially in breast cancer. They could serve as therapeutic targets against breast cancers in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.