Trial reportPain medicine (Malden, Mass.)2010
Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults.
Trial report in Pain medicine (Malden, Mass.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.The pharmacogenomics journal · 2020Trial
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- Trial
- Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.Journal of behavioral medicine · 2013Trial
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- Individual differences in morphine and butorphanol analgesia: a laboratory pain study.Pain medicine (Malden, Mass.) · 2011Trial
- Drug response profiles to experimental pain are opioid and pain modality specific.The journal of pain · 2011Trial
- Comparison of the efficacy of pentazocine and tramadol for reducing emergence agitation in children after general anesthesia: a retrospective cohort study.BMC pediatrics · 2026Article
- Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.Pain research & management · 2022Article
- Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study.Pain and therapy · 2021Article
- Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats.Molecules (Basel, Switzerland) · 2021Article
- Attention Bias Test Measures Negative But Not Positive Affect in Sheep: A Replication Study.Animals : an open access journal from MDPI · 2020Article
- Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling.Molecular brain · 2020Article
- Article
- Opioid system and human emotions.British journal of pharmacology · 2018Review
- Feeding Releases Endogenous Opioids in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Atypical myopathy: pentazocine induced.Innovations in clinical neuroscienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe side effects of opioids have been widely investigated, but it is unknown whether the subjective effects of mu agonists and mixed action opioids produce similar symptom profiles. This study examined the structure and predictive validity of somatic and cognitive/affective side-effect profiles of morphine and pentazocine using the Somatic Side Effects Questionnaire and the Cognitive and Affective Side Effects Questionnaire.
designThe subjects were 122 female and 90 male healthy volunteers that received an intravenous bolus administration of either 0.08 mg/kg of morphine or 0.5 mg/kg pentazocine. Pre- and post-drug experimental pain testing was also performed. Exploratory and confirmatory factor analysis resulted in similar factor structures for both drugs.
resultsThe most frequently reported side effects across both drugs involved feeling relaxed, sedation, and feeling in control. At equianalgesic doses, pentazocine had greater aversive side effects than morphine, whereas morphine was more associated with feelings of control and euphoria. For both drugs, females reported greater frequency of negative side effects than males. Using cluster analysis, we identified similar symptom profiles for each drug. These drug-related side-effect profiles were linked with analgesic responses. Specifically, groups that had a more positive side-effect profile experienced the greatest analgesic effect based on changes in ischemic pain sensitivity.
conclusionsThese findings have implications for decisions regarding opioid management of acute, chronic, and malignant pain conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.