Trial reportEuropean journal of applied physiology2009
The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia.
Trial report in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01398943 (Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test.Journal of visualized experiments : JoVE · 2016Guideline
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.American journal of physiology. Heart and circulatory physiology · 2011 · on this mapGuideline
- No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation.International journal of sports medicine · 2017Trial
- Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.Hypertension (Dallas, Tex. : 1979) · 2012Trial
- Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults.American journal of hypertension · 2011Trial
- Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress.Oxidative medicine and cellular longevity · 2019Article
- Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study.BMC nephrology · 2018Article
- Vascular function and endothelin-1: tipping the balance between vasodilation and vasoconstriction.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Article
- Neurovascular coupling in humans: Physiology, methodological advances and clinical implications.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
- Further Peripheral Vascular Dysfunction in Heart Failure Patients With a Continuous-Flow Left Ventricular Assist Device: The Role of Pulsatility.JACC. Heart failure · 2015Article
- Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction.Clinical rheumatology · 2015Article
- Can a combination of handgrip exercise and prolonged forearm occlusion elicit a maximal brachial artery FMD response?European journal of applied physiology · 2014Article
- Does brachial artery flow-mediated vasodilation provide a bioassay for NO?Hypertension (Dallas, Tex. : 1979) · 2013Article
- Assessment of endothelial dysfunction in childhood obesity and clinical use.Oxidative medicine and cellular longevity · 2013Review
- Vascular function and the role of oxidative stress in heart failure, heart transplant, and beyond.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Ultrasound assessment of flow-mediated dilation.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Acute oral tetrahydrobiopterin administration ameliorates endothelial dysfunction in systemic sclerosis.Clinical and experimental rheumatologyArticle
- Non-invasive digital thermal monitoring and flow-mediated dilation in systemic sclerosis.Clinical and experimental rheumatologyArticle
- Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbAChronic respiratory diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In light of the current methodological developments in flow-mediated dilation (FMD) testing and the recognition that oxidative stress may play an important role in regulating this process, the present study sought to: (1) compare flow-mediated dilation (FMD) following 5 and 10 min of forearm cuff occlusion, and (2) evaluate the role of oxidative stress on vasodilation, both distal and proximal to the cuff. Of the 14 subjects studied, 6 partook solely in a validation study of the antioxidant cocktail (AOC; vitamins C, E, and alpha-lipoic acid), while the remaining 8 subjects underwent FMD assessment in response to 5 and 10 min of forearm occlusion following ingestion of AOC or placebo. Although the efficacy of the AOC was clearly documented by elevated plasma ascorbate levels (approximately 95%) and a reduced free radical concentration (approximately 65%), no effects of acute oral antioxidants were observed. FMD was significantly augmented in response to 10 min of forearm occlusion when compared to 5 min, whether expressed as % change (10.1 +/- 2 vs. 4.5 +/- 1%, respectively) or absolute change in diameter (0.035 +/- 0.005 vs. 0.018 +/- 0.005 cm, respectively). Additionally, post-occlusion shear rate (28,640 +/- 2,799 vs. 18,629 +/- 1,724/s, AUC), FMD/shear rate (approximately 50%), and time to peak dilation (68 +/- 7 vs. 53 +/- 8 s) were greater following 10 min of occlusion. In contrast to previous studies, this investigation has identified a greater brachial artery FMD in response to 10 versus 5 min of forearm ischemia, which appears to be unexplained by oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.