ArticleEuropean biophysics journal : EBJ2010
Calibration of dynamic models of biological systems with KInfer.
Article in European biophysics journal : EBJ, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Inferring biochemical reaction pathways: the case of the gemcitabine pharmacokinetics.BMC systems biology · 2012Article
- Modelling non-homogeneous stochastic reaction-diffusion systems: the case study of gemcitabine-treated non-small cell lung cancer growth.BMC bioinformatics · 2012Article
- Article
- Elucidation of functional consequences of signalling pathway interactions.BMC bioinformatics · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods for parameter estimation that are robust to experimental uncertainties and to stochastic and biological noise and that require a minimum of a priori input knowledge are of key importance in computational systems biology. The new method presented in this paper aims to ensure an inference model that deduces the rate constants of a system of biochemical reactions from experimentally measured time courses of reactants. This new method was applied to some challenging parameter estimation problems of nonlinear dynamic biological systems and was tested both on synthetic and real data. The synthetic case studies are the 12-state model of the SERCA pump and a model of a genetic network containing feedback loops of interaction between regulator and effector genes. The real case studies consist of a model of the reaction between the inhibitor kappaB kinase enzyme and its substrate in the signal transduction pathway of NF-kappaB, and a stiff model of the fermentation pathway of Lactococcus lactis.
Indexed as
Identifiers
19669750What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.