SynthesisPediatric surgery international2009
A meta-analysis of clinical outcome in patients with total intestinal aganglionosis.
Synthesis in Pediatric surgery international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- A meta-analysis of clinical outcome of intestinal transplantation in patients with total intestinal aganglionosis.Pediatric surgery international · 2017Pooled it
- Associations ofBioscience reports · 2019Trial
- Long-term outcomes in newborn surgery.Pediatric surgery international · 2022Review
- Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.Journal of cellular and molecular medicine · 2021Article
- Color Transition of Meconium: Extensive Type of Hirschsprung Disease.ACG case reports journal · 2021Article
- Correlation analysis of IL-11 polymorphisms and Hirschsprung disease subtype susceptibility in Southern Chinese Children.BMC medical genomics · 2021Article
- Comment on a recent genetic study on the risk profile of Hirschsprung's disease from a pediatric surgeon's perspective.Annals of translational medicine · 2020Article
- Increased Fibronectin Impairs the Function of Excitatory/Inhibitory Synapses in Hirschsprung Disease.Cellular and molecular neurobiology · 2020Article
- Unexpected gap between intraoperative caliber change of the intestine and normoganglia in patients with intestinal aganglionosis.Pediatric surgery international · 2019Article
- Nationwide survey of outcome in patients with extensive aganglionosis in Japan.Pediatric surgery international · 2019Article
- Delayed appearance of mature ganglia in an infant with an atypical presentation of total colonic and small bowel aganglionosis: a case report.BMC pediatrics · 2019Article
- Pleiotropic effect of commonAging · 2019Article
- Article
- The challenges of closing an ileostomy in patients with total intestinal aganglionosis after small bowel transplant.Pediatric surgery international · 2018Article
- Pre-emptive Intestinal Transplant: The Surgeon's Point of View.Digestive diseases and sciences · 2017Review
- Hemophagocytic lymphohistiocytosis presenting in a pediatric patient with near total colonic and small bowel aganglionosis: a case report.Journal of medical case reports · 2017Article
- [Motility disorders of the esophagus].Der Pathologe · 2013Review
- Hirschsprung's disease: what about mortality?Pediatric surgery international · 2011Review
- Case of neonate with total intestinal hirschsprung disease managed with a proximal jejunostomy.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total intestinal aganglionosis (TIA) is the most extreme and rare form of Hirschsprung disease (HD). Until few years ago TIA was considered to be a uniformly fatal condition. Survival has improved in the recent years with the advent of parenteral nutrition, innovative surgical techniques and small bowel transplantation. The purpose of this meta-analysis was to determine the clinical outcome of TIA following various surgical procedures. A meta-analysis of cases of TIA reported in the literature between 1985 and 2009 was performed. Detailed information was recorded regarding the extent of aganglionosis, surgical procedures performed and clinical outcome. In case of survivors, authors of reports were contacted to obtain the up-to-date clinical status of the patient. There were 68 cases of TIA reported worldwide, 40 (58.8%) males and 28 (41.2%) females. 6 (8.8%) patients had extension of aganglionosis up to the stomach, 19 (27.9%) up to the duodenum and 43 (63.2%) patients had aganglionosis up to 20 cm below the duodeno-jejunal flexure. Family history of HD was documented in 10 (14.7%) patients. RET-gene mutation were identified in 10 (71.4%) of the 14 patients investigated of RET germline mutations. Eleven patients (16.2%) died prior to surgical treatment, 25 patients (36.8%) only had jejunostomy, while 20 (29.4%) had Ziegler's myectomy-myotomy. 12 (17.6%) patients received intestinal transplantation (ITx) or combined liver-intestinal transplantation (LITx). Forty-five (66.2%) patients died at ages ranging from 1 day to 8 years. Twenty-three (33.8%) patients were alive; the longest survivor was 10 years old after LITx. Innovative surgical procedures and parenteral nutrition have improved clinical outcome of patients with TIA in recent years. Intestinal transplantation appears promising in the management of TIA.
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