ArticleJournal of materials science. Materials in medicine2010
Nanomechanical characterization of tissue engineered bone grown on titanium alloy in vitro.
Article in Journal of materials science. Materials in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 33 citations in OpenAlex.
- Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing.Frontiers in bioengineering and biotechnology · 2023Article
- Gradient nanostructured titanium stimulates cell responsesAnnals of translational medicine · 2021Article
- Nanoindentation of Soft Biological Materials.Micromachines · 2018Review
- Nanobiomechanics of living cells: a review.Interface focus · 2014Review
- Development and characterization of reinforced poly(L-lactide) scaffolds for bone tissue engineering.Journal of materials science. Materials in medicine · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intensive work has been performed on the characterization of the mechanical properties of mineralised tissues formed in vivo. However, the mechanical properties of bone-like tissue formed in vitro have rarely been characterised. Most research has either focused on compact cortical bone or cancellous bone, whilst leaving woven bone unaddressed. In this study, bone-like mineralised matrix was produced by osteoblasts cultured in vitro on the surface of titanium alloys. The volume of this tissue-engineered bone is so small that the conventional tensile tests or bending tests are implausible. Therefore, nanoindentation techniques which allow the characterization of the test material from the nanoscale to the microscale were adopted. These reveal the apparent elastic modulus and hardness of the calcospherulite crystals (a representative element for woven bone) are 2.35 +/- 0.73 and 0.41 +/- 0.15 GPa, respectively. The nanoscale viscoelasticity of such woven bone was further assessed by dynamic indentation analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.