ArticleJournal of hematopathology2008
Pitfalls in TCR gene clonality testing: teaching cases.
Article in Journal of hematopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Integrated TCRγ Clonality Workflow for Molecular Diagnosis in HTLV-1 Carriers and Adult T-Cell Leukemia/Lymphoma.Diagnostics (Basel, Switzerland) · 2026Article
- Skin manifestations uncover underlying Follicular helper T-cell lymphoma, angioimmunoblastic-type in an immunosuppressed patient.Virchows Archiv : an international journal of pathology · 2026Article
- SLIPPERS Reconsidered: Clinical, Radiological, and Pathological Overlap with PACNS-A Case Report.Reports (MDPI) · 2026Article
- Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing.Oncotarget · 2023Article
- Primary Cutaneous Multifocal Indolent CD8+ T-Cell Lymphoma: A Novel Primary Cutaneous CD8+ T-Cell Lymphoma.Biomedicines · 2023Article
- Experience with the BIOMED-2 standardized polymerase chain reaction protocol for immunoglobulin and T- cell receptor clonality analysis in the Instituto Nacional de Cancerología, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Article
- [Clonality analysis in practice].Der Pathologe · 2021Article
- Article
- Differentiation of lymphocytic-plasmacytic enteropathy and small cell lymphoma in cats using histology-guided mass spectrometry.Journal of veterinary internal medicine · 2020Article
- Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution?PloS one · 2020Article
- T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia.Annals of laboratory medicine · 2019Article
- T cell clonality assessment: past, present and future.Journal of clinical pathology · 2018Review
- Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients.BMC medical genetics · 2017Article
- Next generation predictive biomarkers for immune checkpoint inhibition.Cancer metastasis reviews · 2017Review
- Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.PloS one · 2017Article
- Risk stratification of adult T-cell leukemia/lymphoma using immunophenotyping.Cancer medicine · 2017Article
- Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use.The Journal of molecular diagnostics : JMD · 2017Article
- Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.Journal of hematopathology · 2016Article
- New developments in the pathology of malignant lymphoma. A review of the literature published from September 2015-December 2015.Journal of hematopathology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clonality testing in T-lymphoproliferations has technically become relatively easy to perform in routine laboratories using standardized multiplex polymerase chain reaction protocols for T-cell receptor (TCR) gene analysis as developed by the BIOMED-2 Concerted Action BMH4-CT98-3936. Expertise with clonality diagnostics and knowledge about the biology of TCR gene recombination are essential for correct interpretation of TCR clonality data. Several immunobiological and technical pitfalls that should be taken into account to avoid misinterpretation of data are addressed in this report. Furthermore, we discuss the need to integrate the molecular data with those from immunohistology, and preferably also flow cytometric immunophenotyping, for appropriate interpretation. Such an interactive, multidisciplinary diagnostic model guarantees integration of available data to reach the most reliable diagnosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.