ArticlePlanta2009
Expression balances of structural genes in shikimate and flavonoid biosynthesis cause a difference in proanthocyanidin accumulation in persimmon (Diospyros kaki Thunb.) fruit.
Article in Planta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 105 citations in OpenAlex.
- Developmental Changes in Phenolic Composition and Condensed Tannin Structure in the Skins of Three Table Grape Cultivars: 'Rosetta', 'Shooting Star', and 'Hongju Seedless'.Foods (Basel, Switzerland) · 2026Article
- Comprehensive Phenolic Profiling and Antioxidant Evaluation of Calyx, Rind, and Edible Tissues From Non-Astringent Persimmons (Diospyros kaki).Chemistry & biodiversity · 2026Article
- Developmental dynamics of cellular specialization during proanthocyanidin accumulation in persimmon fruit.Plant physiology · 2026Article
- Hepatocytes as Model for Investigating Natural Senotherapeutic Compounds and Their Effects on Cell Cycle Dynamics and Genome Stability.International journal of molecular sciences · 2025Review
- Two shikimate dehydrogenases play an essential role in the biosynthesis of galloylated catechins in tea plants.Horticulture research · 2025Article
- Elucidation and reconstitution of hydrolyzable tannin biosynthesis.Plant biotechnology (Tokyo, Japan) · 2024Article
- Heterologous gene expression system for the production of hydrolyzable tannin intermediates in herbaceous model plants.Journal of plant research · 2023Article
- Comparative Metabolomic and Transcriptomic Analyses Reveal Distinct Ascorbic Acid (AsA) Accumulation Patterns between PCA and PCNA Persimmon Developing Fruit.International journal of molecular sciences · 2023Article
- Identification of key genes responsible for green and white colored spathes inFrontiers in plant science · 2023Article
- Comparative transcriptomic and metabolomic analyses reveal differences in flavonoid biosynthesis between PCNA and PCA persimmon fruit.Frontiers in plant science · 2023Article
- Investigating phenotypic relationships in persimmon accessions through integrated proteomic and metabolomic analysis of corresponding fruits.Frontiers in plant science · 2023Article
- Transcriptomic profiling analysis to identify genes associated with PA biosynthesis and insolubilization in the late stage of fruit development in C-PCNA persimmon.Scientific reports · 2022Article
- De novo transcriptome revealed genes involved in anthocyanin biosynthesis, transport, and regulation in a mutant of Acer pseudosieboldianum.BMC genomics · 2022Article
- Insights into acylation mechanisms: co-expression of serine carboxypeptidase-like acyltransferases and their non-catalytic companion paralogs.The Plant journal : for cell and molecular biology · 2022Article
- DkmiR397 Regulates Proanthocyanidin Biosynthesis via Negative ModulatingInternational journal of molecular sciences · 2022Article
- Regulation of Plant Tannin Synthesis in Crop Species.Frontiers in genetics · 2022Review
- Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon.BMC plant biology · 2021Article
- Comparative Metabolite and Gene Expression Analyses in Combination With Gene Characterization Revealed the Patterns of Flavonoid Accumulation DuringFrontiers in plant science · 2021Article
- MBW complexes impinge on anthocyanidin reductase gene regulation for proanthocyanidin biosynthesis in persimmon fruit.Scientific reports · 2020Article
- Genome-Wide Analysis of Serine Carboxypeptidase-Like Acyltransferase Gene Family for Evolution and Characterization of Enzymes Involved in the Biosynthesis of Galloylated Catechins in the Tea Plant (Frontiers in plant science · 2020Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persimmon fruits accumulate a large amount of proanthocyanidin (PA) during development. Fruits of pollination-constant and non-astringent (PCNA) type mutants lose their ability to produce PA at an early stage of fruit development, while fruits of the normal (non-PCNA) type remain rich in PA until fully ripened. To understand the molecular mechanism for this difference, we isolated the genes involved in PA accumulation that are differentially expressed between PCNA and non-PCNA, and confirmed their correlation with PA content and composition. The expression of structural genes of the shikimate and flavonoid biosynthetic pathways and genes encoding transferases homologous to those involved in the accumulation of phenolic compounds were downregulated coincidentally only in the PCNA type. Analysis of PA composition using the phloroglucinol method suggested that the amounts of epigallocatechin and its 3-O-gallate form were remarkably low in the PCNA type. In the PCNA type, the genes encoding flavonoid 3'5' hydroxylase (F3'5'H) and anthocyanidin reductase (ANR) for epigallocatechin biosynthesis showed remarkable downregulation, despite the continuous expression level of their competitive genes, flavonoid 3' hydroxylation (F3'H) and leucoanthocyanidin reductase (LAR). We also confirmed that the relative expression levels of F3'5'H to F3'H, and ANR to LAR, were considerably higher, and the PA composition corresponded to the seasonal expression balances in both types. These results suggest that expressions of F3'5'H and ANR are important for PA accumulation in persimmon fruit. Lastly, we tested enzymatic activity of recombinant DkANR in vitro, which is thought to be an important enzyme for PA accumulation in persimmon fruits.
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