ReviewCellular and molecular life sciences : CMLS2009
Regulation of estrogen receptor beta activity and implications in health and disease.
Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application.Biomedicines · 2025Review
- Unanticipated differences in the rat plasma metabolome of genistein and daidzein.Archives of toxicology · 2025Article
- Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα-positive breast cancer.Frontiers in oncology · 2025Review
- Y It Matters-Sex Differences in Fetal Lung Development.Biomolecules · 2022Review
- Role of estrogen receptors in health and disease.Frontiers in endocrinology · 2022Review
- Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases.International journal of molecular sciences · 2021Review
- The prognostic factors of recurrence and survival in female patients with lung adenocarcinoma and breast cancer.Journal of cancer research and clinical oncology · 2020Article
- Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma.Journal of pathology and translational medicine · 2020Article
- Estrogen receptors genotypes and canine mammary neoplasia.BMC veterinary research · 2019Article
- Cytoplasmic expression of estrogen receptor β may predict poor outcome of EGFR-TKI therapy in metastatic lung adenocarcinoma.Oncology letters · 2018Article
- Ancestral resurrection of anthropoid estrogen receptor β demonstrates functional consequences of positive selection.Molecular phylogenetics and evolution · 2017Article
- Estrogen, Estrogen Receptor and Lung Cancer.International journal of molecular sciences · 2017Review
- Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands.ChemMedChem · 2017Article
- Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.Science signaling · 2016Article
- Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors.International journal of environmental research and public health · 2016Article
- The Estrogen Receptor-β Expression in De Quervain's Disease.International journal of molecular sciences · 2015Article
- Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.International journal of clinical and experimental pathology · 2015Article
- Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).Biomedical reports · 2014Article
- Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action.CNS neuroscience & therapeutics · 2013Review
- Thiophene-core estrogen receptor ligands having superagonist activity.Journal of medicinal chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Together with the estrogen receptor (ER) alpha, estrogen receptor beta (ER beta ) mediates many of the physiological effects of estrogens. As ER beta is crucially involved in a variety of important physiological processes, its activity should be tightly regulated. ER beta regulation is achieved by hormone binding as well as by posttranslational modifications of the receptor. Furthermore, ER beta expression levels are under circadian control and can be regulated by DNA methylation of the ER beta promoter region. There are also a number of factors that can interfere with ER beta activity, such as phytoestrogens, endocrine disruptive chemicals, and growth factors. In this article, we outline different mechanisms of ER beta regulation and how they are implicated in various diseases. We also discuss how these insights might help to specifically target ER beta in drug design.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.