ArticleAmino acids2010
L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells.
Article in Amino acids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
70 citing papers in PubMed, 226 citations in OpenAlex.
- A Novel Multi-Component Formulation Reduces Inflammation In Vitro and Clinically Lessens the Symptoms of Chronic Eczematous Skin.International journal of molecular sciences · 2023Trial
- The Effect of Arginine Supplementation on Intestinal Antioxidant Capacity, Whole Blood Cell Count and Antiviral Immune Function of Piglets Infected with Porcine Epidemic Diarrhea Virus.Animals : an open access journal from MDPI · 2026Article
- Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis.Journal of animal science and biotechnology · 2026Article
- SC2-3, a Marine Nutrient Glycopeptide fromFoods (Basel, Switzerland) · 2026Article
- Arginine amino acid, nano particles of zinc oxide, and stock density: Effect on growth performance, intestinal morphology, blood indices, and meat quality in broiler chickens.Poultry science · 2026Article
- Increasing arginine supplementation alleviated heat stress and citrulline can effectively substitute arginine in broilers.Journal of animal science and technology · 2026Article
- Iron Stress Reprograms Enterocyte Metabolism.Metabolites · 2025Article
- Arginine-Mediated Liver Immune Regulation and Antioxidant Defense in Largemouth Bass (Antioxidants (Basel, Switzerland) · 2025Article
- Impacts of dietary arginine supplementation on performance, nutrient digestion and expression of proteins related to milk fatty acid and casein synthesis in early lactating dairy cows.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Potential Use of L-Arginine Amino Acids towards Proliferation and Migratory Speed Rate of Human Dental Pulp Stem Cells.European endodontic journal · 2024Article
- Effects of guanidino acetic acid and betaine supplementation on growth, dietary nutrient digestion and intestinal creatine metabolism in sheep.Veterinary medicine and science · 2024Article
- The Roles of Polyamines in Intestinal Development and Function in Piglets.Animals : an open access journal from MDPI · 2024Review
- Hypoventilation training including maximal end-expiratory breath holding improves the ability to repeat high-intensity efforts in elite judo athletes.Frontiers in physiology · 2024Article
- Article
- The use of chitosan oligosaccharide to improve artemisinin yield in well-watered and drought-stressed plants.Frontiers in plant science · 2023Article
- Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions.Frontiers in physiology · 2023Review
- DietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Branched-chain amino acids regulate intracellular protein turnover in porcine mammary epithelial cells.Amino acids · 2022Article
- Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Effects of dietary arginine in ameliorating the deleterious effects induced by mycotoxins on growth, immune system, body organs in growing pigs.Journal of animal science and technology · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study tested the hypothesis that L-arginine (Arg) may stimulate cell proliferation and prevent lipopolysaccharide (LPS)-induced death of intestinal cells. Intestinal porcine epithelial cells (IPEC-1) were cultured for 4 days in Arg-free Dulbecco's modified Eagle's-F12 Ham medium (DMEM-F12) containing 10, 100 or 350 microM Arg and 0 or 20 ng/ml LPS. Cell numbers, protein concentrations, protein synthesis and degradation, as well as mammalian target of rapamycin (mTOR) and Toll-like receptor 4 (TLR4) signaling pathways were determined. Without LPS, IPEC-1 cells exhibited time- and Arg-dependent growth curves. LPS treatment increased cell death and reduced protein concentrations in IPEC-1 cells. Addition of 100 and 350 microM Arg to culture medium dose-dependently attenuated LPS-induced cell death and reduction of protein concentrations, in comparison with the basal medium containing 10 microM Arg. Furthermore, supplementation of 100 and 350 microM Arg increased protein synthesis and reduced protein degradation in both control and LPS-treated IPEC-1 cells. Consistent with the data on cell growth and protein turnover, addition of 100 or 350 microM Arg to culture medium increased relative protein levels for phosphorylated mTOR and phosphorylated ribosomal protein S6 kinase-1, while reducing the relative levels of TLR4 and phosphorylated levels of nuclear factor-kappaB in LPS-treated IPEC-1 cells. These results demonstrate a protective effect of Arg against LPS-induced enterocyte damage through mechanisms involving mTOR and TLR4 signaling pathways, as well as intracellular protein turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.