ArticleClinical ophthalmology (Auckland, N.Z.)2009
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca.
Article in Clinical ophthalmology (Auckland, N.Z.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation.American journal of ophthalmology · 2017Trial
- Trial
- Biopolymers in Mucoadhesive Eye Drops for Treatment of Dry Eye and Allergic Conditions: Application and Perspectives.Pharmaceutics · 2023Review
- How Can We Best Diagnose Severity Levels of Dry Eye Disease: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Effect of a Natural Eye Drop, Made ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting.Acta ophthalmologica · 2018Review
- SIDRE: Symptomatic Improvement of Dry Eye Study.Clinical optometry · 2017Article
- Clinical evaluation of a nutraceutical diet as an adjuvant to pharmacological treatment in dogs affected by Keratoconjunctivitis sicca.BMC veterinary research · 2016Article
- Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease.Ocular immunology and inflammation · 2016Review
- Comparison of the Anti-Inflammatory Effects of Artificial Tears in a Rat Model of Corneal Scraping.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2016Article
- Accelerated Restoration of Ocular Surface Health in Dry Eye Disease by Self-Retained Cryopreserved Amniotic Membrane.The ocular surface · 2016Article
- Acupuncture therapy is more effective than artificial tears for dry eye syndrome: evidence based on a meta-analysis.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- The relationship between Graves' ophthalmopathy and dry eye syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2015Review
- Topical steroid and non-steroidal anti-inflammatory drugs inhibit inflammatory cytokine expression on the ocular surface in the botulinum toxin B-induced murine dry eye model.Molecular vision · 2012Article
- A review on recent advances in dry eye: Pathogenesis and management.Oman journal of ophthalmology · 2011Article
- [Current therapeutic options in Sjögren's syndrome].Zeitschrift fur Rheumatologie · 2010Review
- Irritable bowel syndrome might be associated with dry eye disease.Annals of gastroenterologyArticle
- Efficacy of 3% diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye.Advances in ophthalmology practice and researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories.
methodsA comprehensive literature survey. RESULTS AND
conclusionKeratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.
Indexed as
Identifiers
19668545PMC2709015W2162038769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.