ArticleClinical ophthalmology (Auckland, N.Z.)2008
Alpha antagonists and intraoperative floppy iris syndrome: A spectrum.
Article in Clinical ophthalmology (Auckland, N.Z.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894345 (Open Label 8-Week Study of Prazosin Use in Adults With Anxiety Disorders), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label 8-Week Study of Prazosin Use in Adults With Anxiety Disorders
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Comparing the efficacy of mydriatic cocktail-soaked sponge and conventional pupil dilation in patients using tamsulosin - a randomized controlled trial.BMC ophthalmology · 2013Trial
- Anterior segment, static and dynamic pupillography changes in patients using different types of alpha-1 blockers.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Intraoperative floppy iris syndrome: an updated review of literature.International ophthalmology · 2021Review
- Ten years of intraoperative floppy iris syndrome in the era of α-blockers.Central European journal of urology · 2018Review
- Evaluation of Anterior Segment Changes of Patients Taking Alpha1-Blockers by Ultrasound Biomicroscopy in the Drug-free Period.Turkish journal of ophthalmology · 2017Article
- Lower urinary tract symptoms in men.BMJ (Clinical research ed.) · 2014Review
- Effect of tamsulosin on iris vasculature and morphology.Journal of cataract and refractive surgery · 2014Article
- Intraoperative floppy iris syndrome (IFIS) in patients receiving tamsulosin or doxazosin-a UK-based comparison of incidence and complication rates.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Urologic medications and ophthalmologic side effects: a review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2012Article
- Complications of cataract surgery in patients with BPH treated with alpha 1A-blockers.Central European journal of urology · 2011Review
- Intraoperative Floppy Iris Syndrome Induced by Tamsulosin: The Risk and Preventive Strategies.Middle East African journal of ophthalmologyReview
- Floppy iris syndrome with oral imipramine: a case series.Indian journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine occurrence of features of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients taking systemic alpha-antagonists (AA).
methodsWe prospectively studied patients on AA and who underwent phacoemulsification. The following were recorded: pupil diameter preoperatively, iris flaccidity, iris prolapse and peroperative miosis.
resultsWe studied 40 eyes of 31 subjects. Mean age was 78 years. Overall, 14 eyes (13 patients) showed signs of IFIS: 9/13 (69%) eyes of patients on tamsulosin, 1/18 (6%) eyes in the doxazosin group, 2/2 prazosin patients, 1/4 eyes in the indoramin group, and 1/2 eyes in two patients on a combination of doxazosin and tamsulosin. Most cases (92%) had only one or two signs of IFIS. Bilateral cataract surgery was undertaken in 9 patients but only one patient (on tamsulosin) had features of IFIS in both eyes, while 4 patients (2 on tamsulosin and 2 on other AA) showed signs of IFIS in one eye only, and 4 patients did not show IFIS in either eye.
conclusionMost AA were associated with IFIS, but it tends to present as a spectrum of signs rather than full triad originally described. Tamsulosin was most likely to be associated with IFIS; however, its intake does not necessarily mean that IFIS will occur. For patients on AA, the behavior of the iris intraoperatively in one eye is a poor predictor of the other eye. Surgeons should anticipate the occurrence of IFIS in any patient on AA.
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