ArticleClinical ophthalmology (Auckland, N.Z.)2008
Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy.
Article in Clinical ophthalmology (Auckland, N.Z.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- The selective retinoic acid receptor-α agonist AM580 fails to control autoimmune neuroinflammation.Cellular & molecular immunology · 2019Article
- Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury.PloS one · 2016Article
- Transcriptomic comparison of the retina in two mouse models of diabetes.Journal of ocular biology, diseases, and informatics · 2009Article
- Looking forward to another exciting year of Clinical Ophthalmology.Clinical ophthalmology (Auckland, N.Z.) · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was conducted to investigate whether retinoic acids (RAs) had any effect on apoptosis during the development of diabetic retinopathy.
methodsTo investigate whether RAs had any effect on apoptosis during the development of diabetic retinopathy, we housed 32 C57BL/6 male mice and induced diabetes in 24 by intra peritoneal injections of streptozotocin (STZ; Sigma, St Louis, MO) and treated 16 of the diabetic mice with the RAs, all-trans-retinoic acid (ATRA) (seven mice) and 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido] benzoic acid (Am580) (nine mice). The other eight mice were used as diabetic controls. We then measured apoptosis in the retina by TdT-dUTP terminal nick-end labeling assay.
resultsRAs inhibited the apoptosis of retinal cells in diabetic retinopathy. Many apoptotic cells were observed in retinas of the eight diabetic control mice (mean value and SD: 37.8 +/- 6.9), whereas when diabetic mice were treated with RAs, the number of apoptotic cells significantly decreased (mean value and SD: 9.9 +/- 6.4 for the seven ATRA-treated diabetic mice and 9.8 +/- 5.9 for the nine Am580-treated diabetic mice) (p < 0.05).
conclusionTreatment with RAs decreases apoptosis during the development of diabetic retinopathy.
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Registered trials
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