Evidence map›Paper›PMID 19668086›Full record

SynthesisJournal of acquired immune deficiency syndromes (1999)2009

Alcohol use and antiretroviral adherence: review and meta-analysis.

Christian S Hendershot, Susan A Stoner, David W Pantalone, Jane M Simoni

3 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of acquired immune deficiency syndromes (1999), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 330 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
330citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02356185 unknown statusnot on this mapstarted 2015, after this paper: background citation

Prevalence, Socio-demographic Correlates of Substance Use Disorders Among HIV-infected Adults in Cameroon, and Their Influence on Adherence to Antiretroviral Therapy and Immunological Feature: Study Protocol for a Retrospective Cohort Study

TypeobservationalSponsorGoulfey Health District UnitRan2015 to 2015Enrolled1,000ConditionsHIV
NCT03302299 phase4completednot on this mapstarted 2017, after this paper: background citation

URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy for HIV-infected Alcohol Users in Uganda: an Evaluation of Safety Tolerability and Adherence

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2021Enrolled302ConditionsTuberculosis, HIV/AIDS, Alcohol AbuseArmsIsoniazid 300 Mg ORAL TABLET, Pyridoxine 25 Mg Oral Tablet
NCT06415357 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Adapting mHealth Interventions to Improve Self-management of HIV and Substance Use Among Emerging Adults in Zambia

TypeinterventionalSponsorUniversity of Massachusetts, WorcesterRan2024 to 2026Enrolled164ConditionsPre-Exposure ProphylaxisArmsMobile Healthy Choices (mHC), Motivational Text Messaging (MTM), Standard ART Counseling
3 · Its place in the literature

Who cites it

330 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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270 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian S HendershotDepartment of Psychology, University of Washington, Seattle, WA 98195, USA. chender@u.washington.edu
Susan A Stoner
David W Pantalone
Jane M Simoni

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
ALDH2, ADH1B and Alcohol Expectancies in Asian AmericansF31AA016440 · NIAAA · UNIVERSITY OF WASHINGTON · PI HENDERSHOT, CHRISTIAN S · 2006 to 2008
$98k
NIAAA NIH HHS F31 AA016440NIAAA NIH HHS F31AA016440NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

backgroundAlcohol use is frequently implicated as a factor in nonadherence to highly active antiretroviral therapy (HAART). There have not been efforts to systematically evaluate findings across studies. This meta-analysis provides a quantitative evaluation of the alcohol-adherence association by aggregating findings across studies and examining potential moderators.

methodsLiterature searches identified 40 qualifying studies totaling over 25,000 participants. Studies were coded on several methodological variables.

resultsIn the combined analysis, alcohol drinkers were approximately 50%-60% as likely to be classified as adherent [odds ratio (OR) = 0.548, 95% confidence interval (CI): 0.490 to 0.612] compared with abstainers (or those who drank relatively less). Effect sizes for problem drinking, defined as meeting the National Institute on Alcohol Abuse and Alcoholism criteria for at-risk drinking or criteria for an alcohol use disorder, were greater (OR = 0.474, 95% CI = 0.408 to 0.550) than those reflecting any or global drinking (OR = 0.604, 95% CI = 0.531 to 0.687). Several variables moderated the alcohol-adherence association.

conclusionsResults support a significant and reliable association of alcohol use and medication nonadherence. Methodological variables seem to moderate this association and could contribute to inconsistent findings across studies. Future research would benefit from efforts to characterize theoretical mechanisms and mediators and moderators of the alcohol-adherence association.

Indexed as

Drug MonitoringAlcohol DrinkingAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveHIV InfectionsHumansAnti-HIV Agents

Identifiers

PMID19668086
PMCPMC2815237

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.