ArticleBehavioural pharmacology2009
Quantitative analysis of the effect of lesions of the subthalamic nucleus on intertemporal choice: further evidence for enhancement of the incentive value of food reinforcers.
Article in Behavioural pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
- Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats.Behavioral neuroscience · 2017Article
- Inhibiting subthalamic nucleus decreases cocaine demand and relapse: therapeutic potential.Addiction biology · 2017Article
- Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.Psychopharmacology · 2017Article
- Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson's disease.Scientific reports · 2016Article
- Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.Neurobiology of learning and memory · 2016Review
- Recent Translational Findings on Impulsivity in Relation to Drug Abuse.Current addiction reports · 2014Article
- Do the adjusting-delay and increasing-delay tasks measure the same construct: delay discounting?Behavioural pharmacology · 2014Article
- An examination of the effects of subthalamic nucleus inhibition or μ-opioid receptor stimulation on food-directed motivation in the non-deprived rat.Behavioural brain research · 2012Article
- Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice.Psychopharmacology · 2012Article
- Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition.Neuroscience and biobehavioral reviews · 2010Review
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7 authors.
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Abstract
Recent evidence suggests that the subthalamic nucleus (STN) is involved in regulating the incentive value of food reinforcers. The objective of this study was to examine the effect of lesions of the STN on intertemporal choice (choice between reinforcers differing in size and delay). Rats with bilateral quinolinic acid-induced lesions of the STN (n = 15) or sham lesions (n = 14) were trained in a discrete-trials progressive delay schedule to press levers A and B for a sucrose solution. Responses on A delivered 50 microl of the solution after a delay d(A); responses on B delivered 100 microl after a delay d(B). d(B) increased across blocks of trials; d(A) was manipulated across phases of the experiment. Indifference delay, d(B(50)) (value of d(B) corresponding to 50% choice of B), was estimated for each rat in each phase, and linear indifference functions (d(B(50)) vs. d(A)) were derived. The STN-lesioned group showed a flatter slope of the indifference function (implying higher instantaneous reinforcer values) than the sham-lesioned group; the intercepts did not differ between the groups. The results agree with recent evidence for a role of the STN in incentive value. Unlike some earlier studies, these results do not indicate a role of the STN in delay discounting.
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