Evidence map›Paper›PMID 19667960›Full record

ReviewTransplantation2009

Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome.

Tina L Sumpter, John G Lunz, A Jake Demetris, Angus W Thomson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tina L SumpterStarzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
John G Lunz
A Jake Demetris
Angus W Thomson

Funding

Interdisciplinary Training in Transplantation BiologyT32AI074490 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Angus W Thomson · 2007 to 2026
$4.2M
Plasmacytoid Dendritic Cells and Transplant ToleranceR01AI060994 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2005 to 2008
$1.1M
NIAID NIH HHS R01 AI060994NIAID NIH HHS R01 AI60994NIAID NIH HHS T32 AI074490NIAID NIH HHS T32 AI74490
6 · The paper itself

Abstract

Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.

Indexed as

AnimalsAntigen-Presenting CellsDendritic CellsEndotoxinsGraft SurvivalHumansImmune ToleranceInterleukin-10Interleukin-12LiverLiver TransplantationMiceToll-Like Receptor 10Toll-Like ReceptorsTransplantation, HomologousTreatment OutcomeEndotoxinsInterleukin-10Interleukin-12TLR10 protein, humanTlr13 protein, mouseToll-Like Receptor 10Toll-Like Receptors

Identifiers

PMID19667960
PMCPMC2788312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.