ArticleArchives of internal medicine2009
Lactation and incidence of premenopausal breast cancer: a longitudinal study.
Article in Archives of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review.Toxicological sciences : an official journal of the Society of Toxicology · 2023Pooled it
- Breastfeeding and maternal health outcomes: a systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2015Pooled it
- Postplacental or delayed levonorgestrel intrauterine device insertion and breast-feeding duration.Contraception · 2011Trial
- Article
- Safety of Drugs in Breastfeeding Women With CKD.Kidney international reports · 2025Article
- Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts.Breast cancer research : BCR · 2025Article
- Comparison of Hematological Parameters and the Associated Factors Among Women with and without Breast Cancer: A Case-Control Study.Breast cancer (Dove Medical Press) · 2024Article
- Human Breast Organoid Models for Lactation Research.Reproduction and breeding · 2023Article
- A Narrative Review of Breastfeeding and Its Correlation With Breast Cancer: Current Understanding and Outcomes.Cureus · 2023Review
- Mother and newborn skin-to-skin contact and timely initiation of breastfeeding in sub-Saharan Africa.PloS one · 2023Article
- Breastfeeding duration and subsequent risk of mortality among US women: A prospective cohort study.EClinicalMedicine · 2022Article
- Benefits and issues of education program for nurse-midwives on milk expression care for preterm mothers in postpartum period.Heliyon · 2022Article
- Targeting the purinergic pathway in breast cancer and its therapeutic applications.Purinergic signalling · 2021Review
- Women who breastfeed exhibit cognitive benefits after age 50.Evolution, medicine, and public health · 2021Article
- Knowledge of the Relationship Between Breastfeeding and Breast Cancer Risk Among Racial and Ethnic Minority Women.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women.BMC cancer · 2019Article
- Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.Annals of internal medicine · 2019Article
- Breastfeeding and the Benefits of Lactation for Women's Health.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018Review
- Breast Cancer Prevention: Current Approaches and Future Directions.European journal of breast health · 2018Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFindings from observational studies suggest an inverse association between lactation and premenopausal breast cancer risk, but results are inconsistent, and data from large prospective cohort studies are lacking.
methodsWe used information from 60,075 parous women participating in the prospective cohort study of the Nurses' Health Study II from 1997 to 2005. Our primary outcome was incident premenopausal breast cancer.
resultsWe ascertained 608 incident cases of premenopausal breast cancer during 357,556 person-years of follow-up. Women who had ever breastfed had a covariate-adjusted hazard ratio (HR) of 0.75 (95% confidence interval [CI], 0.56-1.00) for premenopausal breast cancer compared with women who had never breastfed. No linear trend was found with duration of total lactation (P = .95), exclusive lactation (P = .74), or lactation amenorrhea (P = .88). The association between lactation and premenopausal breast cancer was modified by family history of breast cancer (P value for interaction = .03). Among women with a first-degree relative with breast cancer, those who had ever breastfed had a covariate-adjusted HR of 0.41 (95% CI, 0.22-0.75) for premenopausal breast cancer compared with women who had never breastfed, whereas no association was observed among women without a family history of breast cancer.
conclusionIn this large, prospective cohort study of parous premenopausal women, having ever breastfed was inversely associated with incidence of breast cancer among women with a family history of breast cancer.
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