ArticleProceedings of the National Academy of Sciences of the United States of America2009
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- StaVia: spatially and temporally aware cartography with higher-order random walks for cell atlases.Genome biology · 2024Article
- FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.Journal of virology · 2023Article
- FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression.Cell reports · 2022Article
- Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child.EMBO molecular medicine · 2021Article
- Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity.World journal of biological chemistry · 2019Review
- HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell.Cancers · 2018Article
- HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration.Nature communications · 2017Article
- Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV.Journal of virology · 2016Article
- Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line.Journal of visualized experiments : JoVE · 2016Article
- HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.Nature communications · 2015Article
- MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia.Frontiers in cellular neuroscience · 2015Article
- Article
- Impact of viral factors on subcellular distribution and RNA export activity of HIV-1 rev in astrocytes 1321N1.PloS one · 2013Article
- Mouse MCP1 C-terminus inhibits human MCP1-induced chemotaxis and BBB compromise.Journal of neurochemistry · 2011Article
- PDZD8 is a novel Gag-interacting factor that promotes retroviral infection.Journal of virology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons are one of the few cell types in the human body that do not support HIV type-1 (HIV-1) replication. Although the lack of key receptors is a major obstacle to infection, studies suggest that additional functions inhibit virus replication to explain the exquisite resistance of neurons to HIV-1. However, specific neuronal factors that may explain this resistance remain to be discovered. In a screen for antiviral factors using a fibroblast line chemically mutagenized and selected for resistance to retroviral infection, we recently identified induction of rat FEZ1 (fasciculation and elongation protein zeta-1), a brain-specific protein, as the cause of this resistance. When exogenously expressed in nonneuronal cell lines rat FEZ1 blocked nuclear entry of retroviral DNA. Here, we demonstrate that among human brain cells, neurons naturally express high levels of FEZ1 compared to astrocytes or microglia cells and are correspondingly less susceptible to infection with pseudotyped HIV-1 that bypasses receptor-mediated viral entry. Demonstrating that endogenous FEZ1 was functionally important in the resistance of neurons to HIV-1 infection, siRNA-mediated knockdown of endogenous FEZ1 increased the infectivity of neurons while sensitive brain cell types like microglia became more resistant upon FEZ1 overexpression. In addition, FEZ1 expression was not induced in response to IFN treatment. As such, in contrast to other widely expressed, IFN-inducible antiviral factors, FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.