ArticleGenetics2009
Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Modeling homologous chromosome recognition via nonspecific interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-Scale Organization of theGenes · 2021Review
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment.Journal of experimental & clinical cancer research : CR · 2017Article
- A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation.Scientific reports · 2017Article
- Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei.PLoS genetics · 2016Article
- Long-Range Chromatin Interactions.Cold Spring Harbor perspectives in biology · 2015Review
- Disruption of the protein kinase N gene of drosophila melanogaster results in the recessive delorean allele (pkndln) with a negative impact on wing morphogenesis.G3 (Bethesda, Md.) · 2014Article
- Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development.PLoS genetics · 2013Article
- Restoration of topoisomerase 2 function by complementation of defective monomers in Drosophila.Genetics · 2012Article
- Transvection is common throughout the Drosophila genome.Genetics · 2012Article
- Homologue pairing in flies and mammals: gene regulation when two are involved.Genetics research international · 2012Article
- Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster.Genetics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Homologous chromosomes are paired in somatic cells of Drosophila melanogaster. This pairing can lead to transvection, which is a process by which the proximity of homologous genes can lead to a change in gene expression. At the yellow gene, transvection is the basis for several examples of intragenic complementation involving the enhancers of one allele acting in trans on the promoter of a paired second allele. Using complementation as our assay, we explored the chromosomal requirements for pairing and transvection at yellow. Following a protocol established by Ed Lewis, we generated and characterized chromosomal rearrangements to define a region in cis to yellow that must remain intact for complementation to occur. Our data indicate that homolog pairing at yellow is efficient, as complementation was disrupted only in the presence of chromosomal rearrangements that break<or=650 kbp from yellow. We also found that three telomerically placed chromosomal duplications, containing approximately 700 or more kbp of the yellow genomic region, are able to alter complementation at yellow, presumably through competitive pairing interactions. These results provide a formal demonstration of the pairing-dependent nature of yellow transvection and suggest that yellow pairing, as measured by transvection, reflects the extent of contiguous homology flanking the locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.