ArticleThe Journal of cell biology2009
Evolution of complexity in the integrin adhesome.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Integrin-Talin axis regulates mechanosensory presynaptic development and behavioral habituation to mechanical stimulation.G3 (Bethesda, Md.) · 2026Article
- Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development.PLoS genetics · 2024Article
- Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub.bioRxiv : the preprint server for biology · 2023Article
- SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans.Scientific reports · 2022Article
- Review
- Adhesion ofFrontiers in cell and developmental biology · 2022Review
- Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Sea Urchin as a Universal Model for Studies of Gene Networks.Frontiers in genetics · 2020Review
- The Members of the Highly DiverseFrontiers in immunology · 2020Article
- Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells.Investigative ophthalmology & visual science · 2017Article
- Integrative systems and synthetic biology of cell-matrix adhesion sites.Cell adhesion & migration · 2016Review
- Evolutionary Changes on the Way to Clathrin-Mediated Endocytosis in Animals.Genome biology and evolution · 2016Article
- Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells.PloS one · 2016Article
- Cortical actin regulation modulates vascular contractility and compliance in veins.The Journal of physiology · 2015Article
- Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.Nature communications · 2015Article
- Pre-metazoan origins and evolution of the cadherin adhesome.Biology open · 2014Article
- Modulation of C. elegans touch sensitivity is integrated at multiple levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.Molecular & cellular proteomics : MCP · 2013Article
- Mechanosensitivity and compositional dynamics of cell-matrix adhesions.EMBO reports · 2013Review
- Turnover of focal adhesions and cancer cell migration.International journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Integrin-mediated adhesion is as ancient as multicellularity, but it was not always as complex as it is in humans. Here, I examine the extent of conservation of 192 adhesome proteins across the genomes of nine model organisms spanning one and a half billion years of evolution. The work reveals that Rho GTPases, lipid- and serine/threonine-kinases, and phosphatases existed before integrins, but tyrosine phosphorylation developed concomitant with integrins. The expansion of specific functional groups such as GAPs, GEFs, adaptors, and receptors is demonstrated, along with the expansion of specific protein domains, such as SH3, PH, SH2, CH, and LIM. Expansion is due to gene duplication and creation of families of paralogues. Apparently, these paralogues share few partners and create new sets of interactions, thus increasing specificity and the repertoire of integrin-mediated signaling. Interestingly, the average number of interactions positively correlates with the evolutionary age of proteins. While shedding light on the evolution of adhesome complexity, this analysis also highlights the relevance and creates a framework for studying integrin-mediated adhesion in simpler model organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.