Trial reportCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2009
Improving the quality of care for infants: a cluster randomized controlled trial.
Trial report in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02600195 (Reduction of Infection in Neonatal Intensive Care Units Using the Evidence-based Practice for Improving Quality), which is not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reduction of Infection in Neonatal Intensive Care Units Using the Evidence-based Practice for Improving Quality: A Cluster Randomised Trial
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Pooled it
- Early removal versus expectant management of central venous catheters in neonates with bloodstream infection.The Cochrane database of systematic reviews · 2016Pooled it
- Antibiotic lock for the prevention of catheter-related infection in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- The effectiveness of toolkits as knowledge translation strategies for integrating evidence into clinical care: a systematic review.BMJ open · 2015Pooled it
- Evaluation of the Family Integrated Care model of neonatal intensive care: a cluster randomized controlled trial in Canada and Australia.BMC pediatrics · 2015Trial
- Effect of a quality improvement program on weaning from mechanical ventilation: a cluster randomized trial.Intensive care medicine · 2015Trial
- Effectiveness of disseminating consensus management recommendations for ulcer bleeding: a cluster randomized trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Trial
- Prevalence and risk factors for neonatal sepsis among very preterm infants in China: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Impact of a clinical encounter time protection program on pain management: a retrospective difference-in-difference study.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2025Observational
- The role of QI collaboratives in neonatology.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Antimicrobial utilisation patterns between 2013 and 2022 in Canadian neonates born at less than 33 weeks gestation: a retrospective cohort study.Lancet regional health. Americas · 2024Article
- Parent-Integrated Interventions to Improve Language Development in Children Born Very Preterm.Children (Basel, Switzerland) · 2023Article
- GloveCare: a pilot study in preparation for a cluster crossover randomized controlled trial of non-sterile glove-based care in preventing late-onset infection in the NICU.Pilot and feasibility studies · 2023Article
- Advancements in neonatology through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Chinese Neonatal Network: a national protocol for collaborative research and quality improvement in neonatal care.BMJ open · 2022Article
- Hemodynamic Quality Improvement Bundle to Reduce the Use of Inotropes in Extreme Preterm Neonates.Paediatric drugs · 2022Article
- Impact of a "Brain Protection Bundle" in Reducing Severe Intraventricular Hemorrhage in Preterm Infants <30 Weeks GA: A Retrospective Single Centre Study.Children (Basel, Switzerland) · 2021Article
- Neonatal follow-up programs in Canada: A national survey.Paediatrics & child health · 2021Article
- Outcomes and care practices for preterm infants born at less than 33 weeks' gestation: a quality-improvement study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation.Pediatrics · 2019Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe developed and tested a new method, called the Evidence-based Practice for Improving Quality method, for continuous quality improvement.
methodsWe used cluster randomization to assign 6 neonatal intensive care units (ICUs) to reduce nosocomial infection (infection group) and 6 ICUs to reduce bronchopulmonary dysplasia (pulmonary group). We included all infants born at 32 or fewer weeks gestation. We collected baseline data for 1 year. Practice change interventions were implemented using rapid-change cycles for 2 years.
resultsThe difference in incidence trends (slopes of trend lines) between the ICUs in the infection and pulmonary groups was - 0.0020 (95% confidence interval [CI] - 0.0007 to 0.0004) for nosocomial infection and - 0.0006 (95% CI - 0.0011 to - 0.0001) for bronchopulmonary dysplasia.
interpretationThe results suggest that the Evidence-based Practice for Improving Quality method reduced bronchopulmonary dysplasia in the neonatal ICU and that it may reduce nosocomial infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.