ArticleThe Journal of heredity
QTL underlying voluntary exercise in mice: interactions with the "mini muscle" locus and sex.
Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Contribution of Chromosome 14 to Exercise Capacity and Training Responses in Mice.Frontiers in physiology · 2019Article
- Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.Medicine and science in sports and exercise · 2018Review
- Genetic approaches in comparative and evolutionary physiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Article
- A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia.Scientific reports · 2014Article
- Article
- Differential gene expression in high- and low-active inbred mice.BioMed research international · 2014Article
- Effect of chromosome substitution on intrinsic exercise capacity in mice.F1000Research · 2014Article
- Article
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
- Sex-specific heterosis in line crosses of mice selectively bred for high locomotor activity.Behavior genetics · 2011Article
- Architecture of energy balance traits in emerging lines of the Collaborative Cross.American journal of physiology. Endocrinology and metabolism · 2011Article
- Epistatic interactions of genes influence within-individual variation of physical activity traits in mice.Genetica · 2011Article
- Current understanding of the genetic basis for physical activity.The Journal of nutrition · 2011Article
- Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture.Physiological genomics · 2011Article
- How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels.Proceedings. Biological sciences · 2011Article
- The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives.The Journal of experimental biology · 2011Review
- Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice.Frontiers in genetics · 2011Article
- Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression.BMC genetics · 2010Article
- A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice.BMC genetics · 2010Article
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Authors and funding
5 authors.
Funding
Abstract
Exercise improves many aspects of human health, yet many people remain inactive even when exercise is prescribed. We previously created a backcross (BC) between mice selectively bred for high levels of voluntary wheel running (VWR) and fixed for "mini muscle" (MM), a recessive mutation causing approximately 50% reduction in triceps surae mass. We previously showed that BC mice having the MM trait ran faster and further than mice without MM and that MM maps to chromosome 11. Here, we genotyped the BC with genome-wide single nucleotide polymorphisms to identify quantitative trait loci (QTL) controlling voluntary exercise and tissue and body mass traits and to determine whether these QTL interact with the MM locus or with sex. We detected 3 VWR QTL, representing the first voluntary exercise QTL mapped using this high running selection line, and 5 tissue mass QTL. Several interactions between trait QTL and the MM locus as well as sex were also identified. These results begin to explain the genetic architecture of VWR and further support MM as a locus having major effects, including its main effects on the muscle phenotype, its pleiotropic effects on wheel running and tissue mass traits, and through its interactions with other QTL and with sex.
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