ArticleMolecular biology and evolution2009
Cross-sectional dating of novel haplotypes of HERV-K 113 and HERV-K 115 indicate these proviruses originated in Africa before Homo sapiens.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations.Journal of molecular evolution · 2025Review
- Limitations of current high-throughput sequencing technologies lead to biased expression estimates of endogenous retroviral elements.NAR genomics and bioinformatics · 2024Article
- Endogenous retroviral solo-LTRs in human genome.Frontiers in genetics · 2024Review
- Molecular architecture and conservation of an immature human endogenous retrovirus.Nature communications · 2023Article
- Molecular architecture and conservation of an immature human endogenous retrovirus.bioRxiv : the preprint server for biology · 2023Article
- Intragenic L1 Insertion: One Possibility of Brain Disorder.Life (Basel, Switzerland) · 2022Review
- Virus-derived variation in diverse human genomes.PLoS genetics · 2021Article
- Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?Infectious agents and cancer · 2020Article
- Comparative Genomics Analysis Reveals High Levels of Differential Retrotransposition among Primates from the Hominidae and the Cercopithecidae Families.Genome biology and evolution · 2019Article
- Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection.BMC medical genomics · 2019Article
- Border collies of the genome: domestication of an autonomous retrovirus-like transposon.Current genetics · 2019Review
- Biological determinants of health disparities in multiple myeloma.Blood cancer journal · 2018Review
- Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor.Journal of virology · 2016Article
- Genome-wide amplification of proviral sequences reveals new polymorphic HERV-K(HML-2) proviruses in humans and chimpanzees that are absent from genome assemblies.Retrovirology · 2015Article
- Transcriptional activity of human endogenous retroviruses in human peripheral blood mononuclear cells.BioMed research international · 2015Article
- Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.Carcinogenesis · 2014Article
- Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein.Journal of virology · 2014Article
- Human endogenous retroviruses and the nervous system.Handbook of clinical neurology · 2014Review
- Prevalence of human endogenous retroviral element associates with Hodgkin's lymphoma incidence rates.Leukemia research reports · 2014Article
- 'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
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Authors and funding
11 authors.
Funding
Abstract
The human genome, human endogenous retroviruses (HERV), of which HERV-K113 and HERV-K115 are the only known full-length proviruses that are insertionally polymorphic. Although a handful of previously published papers have documented their prevalence in the global population; to date, there has been no report on their prevalence in the United States population. Here, we studied the geographic distribution of K113 and K115 among 156 HIV-1+ subjects from the United States, including African Americans, Hispanics, and Caucasians. In the individuals studied, we found higher insertion frequencies of K113 (21%) and K115 (35%) in African Americans compared with Caucasians (K113 9% and K115 6%) within the United States. We also report the presence of three single nucleotide polymorphism sites in the K113 5' long terminal repeats (LTRs) and four in the K115 5' LTR that together constituted four haplotypes for K113 and five haplotypes for K115. HERV insertion times can be estimated from the sequence differences between the 5' and 3' LTR of each insertion, but this dating method cannot be used with HERV-K115. We developed a method to estimate insertion times by applying coalescent inference to 5' LTR sequences within our study population and validated this approach using an independent estimate derived from the genetic distance between K113 5' and 3' LTR sequences. Using our method, we estimated the insertion dates of K113 and K115 to be a minimum of 800,000 and 1.1 million years ago, respectively. Both these insertion dates predate the emergence of anatomically modern Homo sapiens.
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