ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Transfer of nitric oxide by blood from upstream to downstream resistance vessels causes microvascular dilation.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channelPharmaceutical biology · 2023Article
- Vascular nitric oxide resistance in type 2 diabetes.Cell death & disease · 2023Review
- Transport of nitrite from large arteries modulates regional blood flow during stress and exercise.Frontiers in cardiovascular medicine · 2023Article
- Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation.Journal of the Royal Society, Interface · 2020Article
- The role of gasotransmitters in neonatal physiology.Nitric oxide : biology and chemistry · 2020Review
- Synchronization and Random Triggering of Lymphatic Vessel Contractions.PLoS computational biology · 2016Article
- Novel biomarkers of coronary microvascular disease.Future cardiology · 2016Article
- Emerging trends in the pathophysiology of lymphatic contractile function.Seminars in cell & developmental biology · 2015Review
- Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function.American journal of physiology. Heart and circulatory physiology · 2013Article
- Is the real in vivo nitric oxide concentration pico or nano molar? Influence of electrode size on unstirred layers and NO consumption.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Nitric oxide formation by lymphatic bulb and valves is a major regulatory component of lymphatic pumping.American journal of physiology. Heart and circulatory physiology · 2011Article
- Rapid and slow nitric oxide responses during conducted vasodilation in the in vivo intestine and brain cortex microvasculatures.Microcirculation (New York, N.Y. : 1994) · 2011Article
- Effects of L-arginine pretreatment on nitric oxide metabolism and hepatosplanchnic perfusion during porcine endotoxemia.The American journal of clinical nutrition · 2011Article
- Nitric oxide signaling in the microcirculation.Critical reviews in biomedical engineering · 2011Review
- A computational model for nitric oxide, nitrite and nitrate biotransport in the microcirculation: effect of reduced nitric oxide consumption by red blood cells and blood velocity.Microvascular research · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The discovery that hemoglobin, albumin, and glutathione carry and release nitric oxide (NO) may have consequences for movement of NO by blood within microvessels. We hypothesize that NO in plasma or bound to proteins likely survives to downstream locations. To confirm this hypothesis, there must be a finite NO concentration ([NO]) in arteriolar blood, and upstream resistance vessels must be able to increase the vessel wall [NO] of downstream arterioles. Arteriolar blood NO was measured with NO-sensitive microelectrodes, and vessel wall [NO] was consistently 25-40% higher than blood [NO]. Localized suppression of NO production in large arterioles over 500-1,000 microm with L-nitroarginine reduced the [NO] approximately 40%, indicating as much as 60% of the wall NO was from blood transfer. Flow in mesenteric arteries was elevated by occlusion of adjacent arteries to induce a flow-mediated increase in arterial NO production. Both arterial wall and downstream arteriolar [NO] increased and the arterioles dilated as the blood [NO] was increased. To study receptor-mediated NO generation, bradykinin was locally applied to upstream large arterioles and NO measured there and in downstream arterioles. At both sites, [NO] increased and both sets of vessels dilated. When isoproterenol was applied to the upstream vessels, they dilated, but neither the [NO] or diameter downstream arterioles increased. These observations indicate that NO can move in blood from upstream to downstream resistance vessels. This mechanism allows larger vessels that generate large [NO] to influence vascular tone in downstream vessels in response to both flow and receptor stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.