ArticleEukaryotic cell2009
Aspergillus nidulans protein O-mannosyltransferases play roles in cell wall integrity and developmental patterning.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Structural, Evolutionary, and Functional Analysis of the Protein O-Mannosyltransferase Family in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Identification and Characterization ofCells · 2019Article
- Protein O-mannosyltransferases are required for sterigmatocystin production and developmental processes in Aspergillus nidulans.Current genetics · 2018Article
- Genome sequence of Aspergillus luchuensis NBRC 4314.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi.International journal of molecular sciences · 2016Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- The Pmt2p-Mediated Protein O-Mannosylation Is Required for Morphogenesis, Adhesive Properties, Cell Wall Integrity and Full Virulence of Magnaporthe oryzae.Frontiers in microbiology · 2016Article
- The Penicillium digitatum protein O-mannosyltransferase Pmt2 is required for cell wall integrity, conidiogenesis, virulence and sensitivity to the antifungal peptide PAF26.Molecular plant pathology · 2015Article
- Article
- Investigation of the essentiality of glutamate racemase in Mycobacterium smegmatis.Journal of bacteriology · 2014Article
- Aspergillus nidulans Pmts form heterodimers in all pairwise combinations.FEBS open bio · 2014Article
- GfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O-glycan in Aspergillus nidulans and Aspergillus fumigatus.Molecular microbiology · 2013Article
- The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.The Journal of biological chemistry · 2013Review
- Article
- Botrytis cinerea protein O-mannosyltransferases play critical roles in morphogenesis, growth, and virulence.PloS one · 2013Article
- Putative stress sensors WscA and WscB are involved in hypo-osmotic and acidic pH stress tolerance in Aspergillus nidulans.Eukaryotic cell · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein O-mannosyltransferases (Pmts) initiate O-mannosyl glycan biosynthesis from Ser and Thr residues of target proteins. Fungal Pmts are divided into three subfamilies, Pmt1, -2, and -4. Aspergillus nidulans possesses a single representative of each Pmt subfamily, pmtA (subfamily 2), pmtB (subfamily 1), and pmtC (subfamily 4). In this work, we show that single Deltapmt mutants are viable and have unique phenotypes and that the DeltapmtA DeltapmtB double mutant is the only viable double mutant. This makes A. nidulans the first fungus in which all members of individual Pmt subfamilies can be deleted without loss of viability. At elevated temperatures, all A. nidulans Deltapmt mutants show cell wall-associated defects and increased sensitivity to cell wall-perturbing agents. The Deltapmt mutants also show defects in developmental patterning. Germ tube emergence is early in DeltapmtA and more frequent in DeltapmtC mutants than in the wild type. In DeltapmtB mutants, intrahyphal hyphae develop. All Deltapmt mutants show distinct conidiophore defects. The DeltapmtA strain has swollen vesicles and conidiogenous cells, the DeltapmtB strain has swollen conidiophore stalks, and the DeltapmtC strain has dramatically elongated conidiophore stalks. We also show that AN5660, an ortholog of Saccharomyces cerevisiae Wsc1p, is modified by PmtA and PmtC. The Deltapmt phenotypes at elevated temperatures, increased sensitivity to cell wall-perturbing agents and restoration to wild-type growth with osmoticum suggest that A. nidulans Pmts modify proteins in the cell wall integrity pathway. The altered developmental patterns in Deltapmt mutants suggest that A. nidulans Pmts modify proteins that serve as spatial cues.
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