ArticleProceedings of the National Academy of Sciences of the United States of America2009
Origins of phase contrast in the atomic force microscope in liquids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 115 citations in OpenAlex.
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- Data acquisition and imaging using wavelet transform: a new path for high speed transient force microscopy.Nanoscale advances · 2021Article
- Atomic force microscopy of phase separation on ruptured, giant unilamellar vesicles, and a mechanical pathway for the co-existence of lipid gel phases.Journal of biomechanical engineering · 2019Article
- Mapping heterogeneity of cellular mechanics by multi-harmonic atomic force microscopy.Nature protocols · 2018Article
- Theory of Single-Impact Atomic Force Spectroscopy in liquids with material contrast.Scientific reports · 2018Article
- Simultaneous viscosity and density measurement of small volumes of liquids using a vibrating microcantilever.The Analyst · 2017Article
- Multifrequency Force Microscopy of Helical Protein Assembly on a Virus.Scientific reports · 2016Article
- Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Biochemistry · 2016Article
- The Use of Contact Mode Atomic Force Microscopy in Aqueous Medium for Structural Analysis of Spinach Photosynthetic Complexes.Plant physiology · 2015Article
- Dynamic force microscopy simulator (dForce): A tool for planning and understanding tapping and bimodal AFM experiments.Beilstein journal of nanotechnology · 2015Article
- Frequency function in atomic force microscopy applied to a liquid environment.Sensors (Basel, Switzerland) · 2014Article
- Exploring the retention properties of CaF2 nanoparticles as possible additives for dental care application with tapping-mode atomic force microscope in liquid.Beilstein journal of nanotechnology · 2014Article
- Challenges and complexities of multifrequency atomic force microscopy in liquid environments.Beilstein journal of nanotechnology · 2014Article
- High-resolution dynamic atomic force microscopy in liquids with different feedback architectures.Beilstein journal of nanotechnology · 2013Article
- Multiple regimes of operation in bimodal AFM: understanding the energy of cantilever eigenmodes.Beilstein journal of nanotechnology · 2013Article
- Wavelet cross-correlation and phase analysis of a free cantilever subjected to band excitation.Beilstein journal of nanotechnology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM) in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of soft biological samples with gentle forces. Under these conditions, we show that the phase contrast derives primarily from a unique energy flow channel that opens up in liquids due to the momentary excitation of higher eigenmodes. Contrary to the common assumption, phase-contrast images in liquids using soft microcantilevers are often maps of short-range conservative interactions, such as local elastic response, rather than tip-sample dissipation. The theory is used to demonstrate variations in local elasticity of purple membrane and bacteriophage 29 virions in buffer solutions using the phase-contrast images.
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