ArticleProceedings of the National Academy of Sciences of the United States of America2009
TRPA channels distinguish gravity sensing from hearing in Johnston's organ.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 171 citations in OpenAlex.
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- The TRP-channel painless mediates substrate stiffness sensing in the legs during Drosophila oviposition.PLoS genetics · 2025Article
- A method for mechanically blocking antennal joints in Drosophila.The Journal of experimental biology · 2025Article
- Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda.BMC genomics · 2025Article
- IFT88 maintains sensory function by localising signalling proteins alongLife science alliance · 2024Article
- Gravisensation and modulation of gravitactic responses by other sensory cues in the monarch butterfly (Danaus plexippus).The Journal of experimental biology · 2023Article
- Inbreeding-Driven Innate Behavioral Changes inBiology · 2023Article
- SAMPL is a high-throughput solution to study unconstrained vertical behavior in small animals.Cell reports · 2023Article
- Genetic analysis of a phenotypic loss in the mechanosensory entrainment of a circalunar clock.PLoS genetics · 2023Article
- Scalable Apparatus to Measure Posture and Locomotion (SAMPL): a high-throughput solution to study unconstrained vertical behavior in small animals.bioRxiv : the preprint server for biology · 2023Article
- The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia inFrontiers in molecular neuroscience · 2023Article
- An insecticide target in mechanoreceptor neurons.Science advances · 2022Article
- Octopamine signaling via OctαR is essential for a well-orchestrated climbing performance of adult Drosophila melanogaster.Scientific reports · 2022Article
- Large-Scale Gravitaxis Assay of Caenorhabditis Dauer Larvae.Journal of visualized experiments : JoVE · 2022Article
- Review
- AFrontiers in cell and developmental biology · 2022Article
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23 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although many animal species sense gravity for spatial orientation, the molecular bases remain uncertain. Therefore, we studied Drosophila melanogaster, which possess an inherent upward movement against gravity-negative geotaxis. Negative geotaxis requires Johnston's organ, a mechanosensory structure located in the antenna that also detects near-field sound. Because channels of the transient receptor potential (TRP) superfamily can contribute to mechanosensory signaling, we asked whether they are important for negative geotaxis. We identified distinct expression patterns for 5 TRP genes; the TRPV genes nanchung and inactive were present in most Johnston's organ neurons, the TRPN gene nompC and the TRPA gene painless were localized to 2 subpopulations of neurons, and the TRPA gene pyrexia was expressed in cap cells that may interact with the neurons. Likewise, mutating specific TRP genes produced distinct phenotypes, disrupting negative geotaxis (painless and pyrexia), hearing (nompC), or both (nanchung and inactive). Our genetic, physiological and behavioral data indicate that the sensory component of negative geotaxis involves multiple TRP genes. The results also distinguish between different mechanosensory modalities and set the stage for understanding how TRP channels contribute to mechanosensation.
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