ArticleProceedings of the National Academy of Sciences of the United States of America2009
ER-resident proteins PDR2 and LPR1 mediate the developmental response of root meristems to phosphate availability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 265 citations in OpenAlex.
- Unfolding of RNA secondary structure impairs RNA stability to fine-tune phosphate starvation responses in rice roots.Plant communications · 2026Article
- Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings.Plant, cell & environment · 2026Article
- Evolution of phosphate scouting in the terrestrial biosphere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Plants Under Stress: Exploring Physiological and Molecular Responses to Nitrogen and Phosphorus Deficiency.Plants (Basel, Switzerland) · 2024Review
- The structure and function of P5A-ATPases.Nature communications · 2024Article
- Opportunity for genome engineering to enhance phosphate homeostasis in crops.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant.International journal of molecular sciences · 2024Review
- Recent advances in research on phosphate starvation signaling in plants.Journal of plant research · 2024Review
- Milestones in understanding transport, sensing, and signaling of the plant nutrient phosphorus.The Plant cell · 2024Review
- A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis.Nature communications · 2024Article
- The miRNA-mRNA Regulatory Modules ofInternational journal of molecular sciences · 2023Article
- Phosphorus Plays Key Roles in Regulating Plants' Physiological Responses to Abiotic Stresses.Plants (Basel, Switzerland) · 2023Review
- Genome-wide association study reveals candidate genes controlling root system architecture under low phosphorus supply at seedling stage inMolecular breeding : new strategies in plant improvement · 2023Article
- A Review: Systemic Signaling in the Regulation of Plant Responses to Low N, P and Fe.Plants (Basel, Switzerland) · 2023Review
- Article
- Endoplasmic reticulum calnexins participate in the primary root growth response to phosphate deficiency.Plant physiology · 2023Article
- Phenotypes and Molecular Mechanisms Underlying the Root Response to Phosphate Deprivation in Plants.International journal of molecular sciences · 2023Review
- Integration of reactive oxygen species and nutrient signalling to shape root system architecture.Plant, cell & environment · 2023Review
- Mutation ofInternational journal of molecular sciences · 2023Article
- Application of CRISPR/Cas system in cereal improvement for biotic and abiotic stress tolerance.Planta · 2022Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate availability of inorganic phosphate (Pi) in the rhizosphere is a common challenge to plants, which activate metabolic and developmental responses to maximize Pi acquisition. The sensory mechanisms that monitor environmental Pi status and regulate root growth via altered meristem activity are unknown. Here, we show that PHOSPHATE DEFICIENCY RESPONSE 2 (PDR2) encodes the single P(5)-type ATPase of Arabidopsis thaliana. PDR2 functions in the endoplasmic reticulum (ER) and is required for proper expression of SCARECROW (SCR), a key regulator of root patterning, and for stem-cell maintenance in Pi-deprived roots. We further show that the multicopper oxidase encoded by LOW PHOSPHATE ROOT 1 (LPR1) is targeted to the ER and that LPR1 and PDR2 interact genetically. Because the expression domains of both genes overlap in the stem-cell niche and distal root meristem, we propose that PDR2 and LPR1 function together in an ER-resident pathway that adjusts root meristem activity to external Pi. Our data indicate that the Pi-conditional root phenotype of pdr2 is not caused by increased Fe availability in low Pi; however, Fe homeostasis modifies the developmental response of root meristems to Pi availability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.