ArticleThe Journal of biological chemistry2009
Antigen specificity of gammadelta T cells depends primarily on the flanking sequences of CDR3delta.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- A novel strategy to screen Bacillus Calmette-Guérin protein antigen recognized by γδ TCR.PloS one · 2011Trial
- Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025Review
- γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition.Cellular & molecular immunology · 2025Article
- Non-structure protein ORF1ab (NSP8) in SARS-CoV-2 contains potential γδT cell epitopes.Frontiers in microbiology · 2022Article
- Human and murine memory γδ T cells: Evidence for acquired immune memory in bacterial and viral infections and autoimmunity.Cellular immunology · 2020Review
- Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis.Cellular & molecular immunology · 2019Article
- Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme.Frontiers in immunology · 2019Article
- Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Review
- Article
- The Vγ9Vδ2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells.Frontiers in immunology · 2014Review
- Generation of human neutralizing monoclonal antibodies against the 2009 pandemic H1N1 virus from peripheral blood memory B lymphocytes.Cellular & molecular immunology · 2013Article
- γδ-T cells: an unpolished sword in human anti-infection immunity.Cellular & molecular immunology · 2013Review
- Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity.The Journal of biological chemistry · 2012Article
- CDR3δ -grafted γ9δ2T cells mediate effective antitumor reactivity.Cellular & molecular immunology · 2012Article
- γδ T cells response to Mycobacterium tuberculosis in pulmonary tuberculosis patients using preponderant complementary determinant region 3 sequence.The Indian journal of medical research · 2011Article
- Flanking V and J sequences of complementary determining region 3 of T cell receptor (TCR) δ1 (CDR3δ1) determine the structure and function of TCRγ4δ1.The Journal of biological chemistry · 2011Article
- Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.Blood · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structural basis that determines the specificity of gammadelta T cell receptor (TCR) recognition remains undefined. Our previous data show that the complementary determining region of human TCRdelta (CDR3delta) is critical to ligand binding. Here we used linear and configurational approaches to examine the roles of V, N-D-N, or J regions in CDR3delta-mediated antigen recognition. Surprisingly, we found that the binding activities of CDR3delta from different gammadelta TCRs to their target tissues and ligands depend on the conserved flanking sequences (V and J) but not as much on the D region of CDR3delta fragment. We further defined the key residues in the V and J regions of CDR3delta fragments, including the cysteine residue in the V fragment and the leucine residue in the J fragment that determine their ligand binding specificity. Our results demonstrate that TCRdelta primarily uses conserved flanking regions to bind ligands. This finding may provide an explanation for the limited number of gammadelta TCR ligands that have as yet been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.