ArticleEuropean journal of medical research2009
Gene expression of circulating tumour cells and its correlation with tumour stage in breast cancer patients.
Article in European journal of medical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Prospective Monitoring of Circulating Epithelial Tumor Cells (CETC) Reveals Changes in Gene Expression during Adjuvant Radiotherapy of Breast Cancer Patients.Current oncology (Toronto, Ont.) · 2021Article
- Personalized Therapy and Liquid Biopsy-A Focus on Colorectal Cancer.Journal of personalized medicine · 2021Review
- Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients.Cancer management and research · 2021Article
- Prognostic role of plasma mammaglobin A expression in breast carcinoma patients: a meta-analysis.OncoTargets and therapy · 2018Review
- Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- Detection of Circulating Tumour Cells from Blood of Breast Cancer Patients via RT-qPCR.Cancers · 2013Article
- Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.Biochimica et biophysica acta · 2011Review
- Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment.European journal of medical research · 2011Article
- Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundBreast cancer (BC) represents one of the leading causes of cancer related deaths worldwide. New tools for diagnostic staging and therapeutic monitoring are needed to improve individualized therapies and improve clinical outcome. The analyses of circulating tumour cells may provide important prognostic information in the clinical setting. MATERIALS AND
methodsCirculating tumour cells (CTC) of 63 BC patients were isolated from peripheral blood (PB) through immunomagnetic separation. Subsequently, RT-PCR or mPCR for the genes ga733.2, muc-1, c-erbB2, mgb-1, spdef and c-erbB2 were performed. Subsequently, expression data were correlated with the tumour stages. Fourteen healthy individuals served as controls.
resultsSignificant correlations with tumour stages were found in single gene analyses of ga733.2, muc-1 and in multi-gene analyses of ga733.2/muc-1/mgb1/ spdef. Furthermore, a significant correlation of Ca 15-3 and all studied genes was also observed.
conclusionHerein, we demonstrated a positive correlation of a gene signature consisting of ga733.2, muc-1, mgb1 and spdef and advanced stages of BC. Moreover, all studied genes and gene patterns revealed a significant correlation with Ca 15-3 positive cases.
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