Evidence map›Paper›PMID 19666243›Full record

ReviewAutonomic neuroscience : basic & clinical2010

Urothelial signaling.

Lori A Birder

Abstract readReview
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Urinary albumin excretion and cancer risk: the PREVEND cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Observational
  9. Article
  10. Article
  11. TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. The aging bladder insights from animal models.Asian journal of urology · 2018
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. New therapeutic directions to treat underactive bladder.Investigative and clinical urology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lori A BirderUniversity of Pittsburgh School of Medicine, A 1207 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. lbirder@pitt.edu
University of Pittsburgh · US

Funding

ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITISR01DK057284 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A · 2000 to 2014
$4.3M
Nitric Oxide in Bladder Neural-Epithelial SignalingR37DK054824 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A · 2007 to 2016
$3.0M
NIDDK NIH HHS P50 DK06439NIDDK NIH HHS R01 DK057284NIDDK NIH HHS R01 DK57284NIDDK NIH HHS R37 DK054824NIDDK NIH HHS R37 DK54824
6 · The paper itself

Abstract

Beyond serving as a simple barrier, there is growing evidence that the urinary bladder urothelium exhibits specialized sensory properties and play a key role in the detection and transmission of both physiological and nociceptive stimuli. These urothelial cells exhibit the ability to sense changes in their extracellular environment including the ability to respond to chemical, mechanical and thermal stimuli that may communicate the state of the urothelial environment to the underlying nervous and muscular systems. Here, we review the specialized anatomy of the urothelium and speculate on possible communication mechanisms from urothelial cells to various cell types within the bladder wall.

Indexed as

Adenosine TriphosphateAnimalsHumansPhysical StimulationReceptors, Purinergic P2Signal TransductionStress, MechanicalTRPC Cation ChannelsUrinary BladderUrotheliumAdenosine TriphosphateReceptors, Purinergic P2TRPC Cation Channels

Identifiers

PMID19666243
PMCPMC2818048
OpenAlexW4234442435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.