ArticleJournal of neuroscience methods2009
Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates.
Article in Journal of neuroscience methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.The European journal of neuroscience · 2024Article
- The Profile of Network Spontaneous Activity and Functional Organization Interplay in Hierarchically Connected Modular Neural Networks In Vitro.Micromachines · 2024Article
- From pixels to connections: exploring in vitro neuron reconstruction software for network graph generation.Communications biology · 2024Review
- Investigating the reliability of the evoked response in human iPSCs-derived neuronal networks coupled to micro-electrode arrays.APL bioengineering · 2023Article
- Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine.Stem cell reviews and reports · 2017Review
- Interfacing Cultured Neurons to Microtransducers Arrays: A Review of the Neuro-Electronic Junction Models.Frontiers in neuroscience · 2016Review
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.Frontiers in cellular neuroscience · 2015Article
- Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays.BMC neuroscience · 2013Article
- Optogenetic stimulation effectively enhances intrinsically generated network synchrony.Frontiers in neural circuits · 2013Article
- Adaptive enhancement of learning protocol in hippocampal cultured networks grown on multielectrode arrays.Frontiers in neural circuits · 2013Article
- Aβ oligomers-induced toxicity is attenuated in cells cultured with NbActiv4™ medium.Neurotoxicity research · 2012Article
- Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies.Journal of neural engineering · 2012Article
- Hippocampal networks on reliable patterned substrates.Journal of neuroscience methods · 2012Article
- Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2010Article
- Chronic network stimulation enhances evoked action potentials.Journal of neural engineering · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We chronically stimulated hippocampal networks in culture for either 0, 1 or 3h/day between 7 and 22 days in culture in an effort to increase spontaneous spike rates and to give these networks some portion of external stimuli that brain networks receive during their formation. Chronic electrical stimulation of hippocampal networks on multi-electrode arrays (MEAs) increased spike rates 2-fold after 3 weeks of culture compared to cultures that received no external stimulation prior to recording. More than 90% of the spikes for all experimental conditions occurred within bursts. The frequency of spikes within a burst increased with time of stimulation during culture up to 2-fold higher (90Hz) compared to networks without chronic stimulation. However, spontaneous overall spike rates did not correlate well with the amount of stimulation either as h/day or proximity to the limited number of stimulation sites due to shorter burst duration with 3h/day stimulation. The results suggest that chronic stimulation applied during network development recruits activity at 50% more electrodes and enables higher rates of spontaneous activity within bursts in cultured hippocampal networks.
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Registered trials
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