Evidence map›Paper›PMID 19665885›Full record

ReviewCurrent opinion in neurobiology2009

Caenorhabditis elegans pheromones regulate multiple complex behaviors.

Arthur S Edison

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Microorganisms · 2021
    Article
  11. Article
  12. Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019
    Review
  13. Novel Technological Advances in Functional Connectomics inJournal of developmental biology · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Arthur S EdisonBox 100245, Department of Biochemistry & Molecular Biology, McKnight Brain Institute, and National High Magnetic Field Laboratory, University of Florida, Gainesville, FL 32610-0245, USA. aedison@ufl.edu

Funding

Comparative Behavioral Metabolomics in NematodesR01GM085285 · NIGMS · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S · 2009 to 2012
$1.5M
NIGMS NIH HHS 1R01GM085285-01NIGMS NIH HHS R01 GM085285
6 · The paper itself

Abstract

A family of small molecules called ascarosides act as pheromones to control multiple behaviors in the nematode Caenorhabditis elegans. At picomolar concentrations, a synergistic mixture of at least three ascarosides produced by hermaphrodites causes male-specific attraction. At higher concentrations, the same ascarosides, perhaps in a different mixture, induce the developmentally arrested stage known as dauer. The production of ascarosides is strongly dependent on environmental conditions, although relatively little is known about the major variables and mechanisms of their regulation. Thus, male mating and dauer formation are linked through a common set of small molecules whose expression is sensitive to a given microenvironment, suggesting a model by which ascarosides regulate the overall life cycle of C. elegans.

Indexed as

AnimalsCaenorhabditis elegansChemoreceptor CellsFeeding BehaviorLarvaSex AttractantsSexual Behavior, AnimalSex Attractants

Identifiers

PMID19665885
PMCPMC2779695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.